rs7453920, HLA-DQB2

N. diseases: 10
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation BEFREE No significant correlation was shown in HLA-DP rs3077 and rs9277535 with HBV infection or liver function recovery (P < .05).Our study concluded that HLA-DP (rs3077 and rs9277535) and HLA-DQ (rs7453920) were not significantly associated with HBV recurrence or HBV susceptibility, but HLA-DQ rs7453920 was related to prognosis of liver transplant recipients. 28640108 2017
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation BEFREE The pooled risk estimates indicated that HLA-DQ rs7453920-A polymorphism was associated with decreased risk of HBV infection, and rs7453920-G serves as a risk factor in HBV infection. 28512640 2017
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation BEFREE These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine. 28882445 2017
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation BEFREE SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. 28267888 2017
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation BEFREE The SNPs of HLA-DQ (rs2856718 and rs7453920) were determined in 299 patients with chronic HBV infection. 27580643 2017
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation BEFREE In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported. 25041342 2015
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation GWASDB We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection. 24940741 2014
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation BEFREE We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection. 24940741 2014
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation GWASDB New loci associated with chronic hepatitis B virus infection in Han Chinese. 24162738 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation GWASCAT New loci associated with chronic hepatitis B virus infection in Han Chinese. 24162738 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation GWASDB A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. 23760081 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation BEFREE Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B virus (HBV) infection in Japanese populations. 22105689 2012
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation GWASCAT A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. 21750111 2011
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.880 GeneticVariation GWASDB A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. 21750111 2011
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.740 GeneticVariation BEFREE Our data show that HLA gene polymorphisms are associated with SI in patients with HBV-related HCC, and the absence of minor allele A (rs7453920) promotes SI and shortens OS. 30104900 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.740 GeneticVariation BEFREE This study revealed an association between rs2856718 and HCC development and an association between rs7453920 and HBsAg levels. 27580643 2017
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.740 GeneticVariation BEFREE HLA-DP/DQ polymorphisms (rs3077, rs9277535, rs7453920) did not associate with HCC development, but did correlate with HBV susceptibility and HBV natural clearance. 25365208 2014
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.740 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.740 GeneticVariation BEFREE Logistic regression analyses showed that HLA-DQ rs2856718 significantly decreased host HCC risk, whereas three SNPs were associated with HBV clearance (HLA-DP rs9277535 as well as HLA-DQ rs7453920 and rs2856718). 22105689 2012
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.720 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. 28882445 2017
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.720 GeneticVariation BEFREE Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population. 28613373 2017
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.720 GeneticVariation GWASCAT Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. 25802187 2015
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.720 GeneticVariation GWASCAT A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. 24940741 2014
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.720 GeneticVariation GWASCAT A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. 23760081 2013
Lupus Erythematosus, Systemic
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
0.700 GeneticVariation GWASDB GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. 24871463 2014