|
Hyperlipoproteinemia Type IIa
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, the T allele of rs1801133 and the G allele of rs751141 may be risk factors of ischemic stroke in the Chinese T2DM population.
|
28409162 |
2017 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction confers a significantly higher risk for IS.
|
25839935 |
2015 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed that certain gene-gene interactions among rs17110453, rs751141, and rs9333025 predict a higher risk for IS (OR=2.36, 95% CI: 1.228-5.297, p=0.005).
|
25947240 |
2015 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
We genotyped participants from the Copenhagen City Heart Study (n=10 352), the Copenhagen General Population Study (n=26 042), the Copenhagen Carotid Stroke Study (n=398 cases+796 control subjects), and the Copenhagen Ischemic Heart Disease Study (n=4901 cases+9798 control subjects) for the R103C, R287Q, and Arg(402-403ins) variants in the EPHX2 gene and recorded hospital admissions due to ischemic stroke, myocardial infarction, and ischemic heart disease.
|
19940276 |
2010 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in previous studies.
|
20065888 |
2010 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Collectively, these data indicate a protective influence of the G860A polymorphism of EPHX2 on ischemic stroke in Chinese nonsmokers.
|
18216721 |
2008 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
This case-control study as well as meta-analysis suggested no association between CYP2J2 G-50T and EPHX2 R287Q and the risk of developing CAD.
|
21642892 |
2011 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in previous studies.
|
20065888 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the A allele of exonic polymorphism in EPHX2 rs751141 is negatively associated with the incidence of DN in the Chinese T2D population, which could be modulated by Hcy level status.
|
29629376 |
2018 |
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the A allele of exonic polymorphism in EPHX2 rs751141 is negatively associated with the incidence of DN in the Chinese T2D population, which could be modulated by Hcy level status.
|
29629376 |
2018 |
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results demonstrate that EPHX2 p.Lys55Arg and p.Arg287Gln polymorphisms do not significantly modify survival after an ACS event.
|
30096423 |
2018 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the association between EPHX2 p.Lys55Arg and p.Arg287Gln genotype with survival in 667 acute coronary syndrome (ACS) patients.
|
30096423 |
2018 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The interactions among variants rs17110453, rs751141, and rs9333025 were significantly associated with high 20-HETE, high DiHETEs, and low EETs after adjusting for the status of diabetes mellitus and hypertension.
|
27087514 |
2016 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The interactions among variants rs17110453, rs751141, and rs9333025 were significantly associated with high 20-HETE, high DiHETEs, and low EETs after adjusting for the status of diabetes mellitus and hypertension.
|
27087514 |
2016 |
|
Essential Hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs751141 allele gene polymorphism may be an independent protective factor against essential hypertension in the Han population.
|
25966114 |
2015 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Eight variants in five candidate genes were examined for the risk of stroke, including the SG13S32 (rs9551963), SG13S42 (rs4769060), SG13S89 (rs4769874), and SG13S114 (rs10507391) variants of the 5-lipoxygenase activating protein (ALOX5AP) gene, the G860A (rs751141) variant of the soluble epoxide hydrolase (EPHX2) gene, the A1075C (rs1057910) variant of the CYP2C9*2 gene, the C430T (rs1799853) variant of the CYP2C9*3 gene, and the A6986G (rs776746) variant of the CYP3A5 gene.
|
24368493 |
2014 |
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of rs751141 polymorphism is associated with a significantly increased risk of AF recurrence after catheter ablation.
|
23711456 |
2013 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations between the EPHX2 Lys55Arg and Arg287Gln polymorphisms and cardiovascular disease risk have been reported; however, their impact on vascular function in humans has not been investigated.
|
21098312 |
2011 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in previous studies.
|
20065888 |
2010 |
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in previous studies.
|
20065888 |
2010 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped participants from the Copenhagen City Heart Study (n=10 352), the Copenhagen General Population Study (n=26 042), the Copenhagen Carotid Stroke Study (n=398 cases+796 control subjects), and the Copenhagen Ischemic Heart Disease Study (n=4901 cases+9798 control subjects) for the R103C, R287Q, and Arg(402-403ins) variants in the EPHX2 gene and recorded hospital admissions due to ischemic stroke, myocardial infarction, and ischemic heart disease.
|
19940276 |
2010 |