|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A single-polymorphism analysis revealed that the TT genotype of the rs7574865/T > G polymorphism was significantly more frequent in women with minimal or mild endometriosis than in the controls (10% vs. 5%, p = 0.047).
|
30887509 |
2019 |
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is the first study demonstrating the significant associations of SNP rs3077, rs9277535 and rs7574865 and the haplotypes in the HLA gene with the risk of IgAN in a Southwest Chinese population.
|
29467950 |
2018 |
|
Myasthenia Gravis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The strongest signals of association were observed in the cases of rs6679356 between the late-onset MG patients and controls and rs7574865 between early-onset MG and controls.
|
29576322 |
2018 |
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b> This meta-analysis showed a significant association between <i>STAT4</i> rs7574865 polymorphism and AITD susceptibility.
|
30666271 |
2018 |
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
<i>STAT4</i> rs7574865 polymorphism was significantly associated both with Graves' disease (GD) and Hashimoto's thyroiditis (HT) susceptibility.
|
30666271 |
2018 |
|
Autoimmune thyroid disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Association Between <i>STAT4</i> rs7574865 Polymorphism and the Susceptibility of Autoimmune Thyroid Disease: A Meta-Analysis.
|
30666271 |
2018 |
|
Autoimmune Chronic Hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk.
|
28977835 |
2017 |
|
Autoimmune hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk.
|
28977835 |
2017 |
|
Neuromyelitis Optica
|
|
0.010 |
GeneticVariation
|
BEFREE |
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
|
28852993 |
2017 |
|
Dermatomyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The strongest association was observed in dermat</span>omyositis, with an OR of 3.07 (95% CI; 1.57-6.02) for the carriers of four risk alleles at the two SNP sites, namely, rs1327713 and rs7574865.
|
24632671 |
2014 |
|
Adult type dermatomyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The strongest association was observed in dermatomyositis, with an OR of 3.07 (95% CI; 1.57-6.02) for the carriers of four risk alleles at the two SNP sites, namely, rs1327713 and rs7574865.
|
24632671 |
2014 |
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the stratified meta-analysis also demonstrate that the STAT4 rs7574865 polymorphism is associated with the presence of autoantibodies with systemic reactivity (anti-ds-DNA antibodies) in SLE patients (OR = 1.37; 95% CI = 1.21 - 1.56, P = 1.12 × 10(-6)).
|
23628400 |
2013 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Detailed genotype-phenotype analysis of type-1 autoimmune hepatitis patients with (n = 44) or without liver cirrhosis (n = 186) demonstrated that rs7574865 was not associated with the development of liver cirrhosis and phenotype (biochemical data and the presence of auto-antibodies).
|
23990947 |
2013 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case-control study was carried out on IRF5 rs10954213 and STAT4 rs7574865 in 232 Japanese myeloperoxidase (MPO)-ANCA-positive AAV patients, including 177 microscopic polyangiitis and 710 healthy controls.
|
23985571 |
2013 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
STAT4 rs7574865 G/T was not associated with susceptibility to AS.
|
23727609 |
2013 |
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that patients with early arthritis who are homozygous for the T allele of rs7574865 in STAT4 may develop a more severe form of the disease with increased disease activity and disability.
|
22937072 |
2012 |
|
Drug-Induced Liver Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
An analysis of hepatocellular DILI (n=285) restricted to 193 single-nucleotide polymorphisms previously associated with autoimmune disease showed a trend association for rs7574865, in the vicinity of signal transducer and activator of transcription 4 (STAT4) (P=4.5×10(-4)).
|
22968431 |
2012 |
|
Idiopathic Pulmonary Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.
|
21149496 |
2011 |
|
Hamman-Rich syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.
|
21149496 |
2011 |
|
Alveolitis, Fibrosing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.
|
21149496 |
2011 |
|
Crohn's disease of large bowel
|
|
0.010 |
GeneticVariation
|
BEFREE |
Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
|
20454450 |
2010 |
|
Uveomeningoencephalitic Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that TT genotype of rs7574865 may be a susceptible factor for VKH syndrome in a Chinese Han population, and that GG genotype of this SNP may confer susceptibility in male BD patients.
|
20438790 |
2010 |
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
GT genotypic frequency was significantly lower in BD patients than in controls (p = 0.003) However the significance of rs7574865 was lost in all tested BD patients when adjusted for gender (p = 0.775).
|
20438790 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that whilst allele T of the STAT4 rs7574865 gene polymorphism is associated with susceptibility to T1D, it is not associated with increased risk for and T2D, and thus does not represent a common genetic factor for diabetes.
|
19371230 |
2009 |
|
Hematological Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
It was showed that rs7574865 of STAT4 is also linked to hematologic disorders and potentially some other subphenotypes of the disease.
|
19225526 |
2009 |