|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent study in the North American White population has documented the association of a common STAT4 haplotype (tagged by rs7574865) with risk for rheumatoid arthritis (RA) and systemic lupus erythematosus.
|
17932559 |
2007 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
To test the hypothesis that the variant haplotype of STAT4 seen in RA and SLE is also associated with pSS, we genotyped rs7574865, the most strongly disease-associated SNP in the variant STAT4 haplotype, in 124 Caucasian pSS subjects and compared them to 1143 Caucasian controls.
|
18273036 |
2008 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.
|
18432273 |
2008 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings indicate an association between the STAT4 polymorphism rs7574865 and RA in 3 different populations, from Spain, Sweden, and The Netherlands, thereby confirming previous data.
|
18576336 |
2008 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Similarly, mutated allele T or genotypes T/T and G/T of the STAT4 rs7574865 SNP were also associated with susceptibility to RA (OR=1.9, 95% CI=1.46-2.50, and OR=2.37, 95% CI 1.73-2.25, respectively).
|
18625278 |
2008 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of STAT4 polymorphism rs7574865 with RA was validated in patients of Spanish origin (for T versus G, P = 1.2 x 10(-6), odds ratio [OR] 1.59, 95% confidence interval [95% CI] 1.31-1.92), and the association was described for the first time in both clinical forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis (for T versus G, P = 0.006, OR 1.29, 95% CI 1.07-1.55), and in type 1 diabetes mellitus (for T versus G, P = 0.008, OR 1.36, 95% CI 1.07-1.71).
|
18759272 |
2008 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, we were able to replicate the association signals between RA and HLA-DRB1 alleles, STAT4 (rs7574865), PTPN22 (rs2476601) and OLIG3/TNFAIP3 (rs10499194 and rs6920220).
|
19445664 |
2009 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results of our meta-analysis demonstrated that STAT4 rs7574865 SNP is significantly associated with RA and SLE.
|
19479340 |
2010 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis confirms that the STAT4 rs7574865 polymorphism is associated with RA susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
|
19588142 |
2010 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.
|
20498205 |
2010 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genotyping of STAT4 rs7574865 single nucleotide polymorphism (SNP) was performed in 140 patients affected with RA, 159 patients affected with AITDs and 200 healthy controls using TaqMan® allelic discrimination assay.
|
21418779 |
2011 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genotype and allele distributions of four polymorphisms were significantly different in individuals with RA compared to controls, with SNP rs7574865 T allele and T/T genotype showing the most significant association with susceptibility to RA (uncorrected P=1×10(-4), OR=1.645, 95% CI=1.272-2.129; uncorrected P=4.8×10(-5), OR=3.111, 95% CI=1.777-5.447, respectively).
|
21683716 |
2011 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
|
22446963 |
2012 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
One of these SNP, rs75</span>74865, showed a similar pattern of the association in serologically distinct subgroups of RA in a metaanalysis of all 7 published studies.
|
22753649 |
2012 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis.
|
22937072 |
2012 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic polymorphism rs7574865 in STAT4 gene might be associated with RA susceptibility in total subjects, major ethnic groups and different status of anti-CCP or RF.
|
23295549 |
2013 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Childhood-onset RA was associated with TNFAIP3 rs10499194 (OR 0.60 [95% confidence interval 0.44-0.83]), PTPN22 rs2476601 (OR 1.61 [95% confidence interval 1.11-2.31]), and STAT4 rs7574865 (OR 1.41 [95% confidence interval 1.06-1.87]) variants.
|
23450725 |
2013 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis revealed that the STAT4 rs7574865 polymorphism is associated with four autoimmune diseases with systemic pathology, including systemic lupus erythematosus (OR = 1.52; 95% CI = 1.48 - 1.56, P<1.0 × 10(-16)), rheumatoid arthritis (OR = 1.27; 95% CI = 1.21 - 1.33, P < 1.00 × 10(-16)), systemic sclerosis (OR = 1.38; 95% CI = 1.27 - 1.50, P < 1.44 × 10(-14)), and primary Sjogren's syndrome (OR = 1.32; 95% CI = 1.01 - 1.73, P = 4.40 × 10(-2)), while no association was found with type I diabetes, juvenile idiopathic arthritis, ulcerative colitis and Crohn's disease.
|
23628400 |
2013 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
This replication study confirmed that STAT4 rs7574865 G/T polymorphism was associated with the risk of RA.
|
23727609 |
2013 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
STAT4 rs7574865 is significantly associated with RA susceptibility in northern Chinese Han subpopulations.
|
23773642 |
2013 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study indicates that the STAT4 rs7574865 G/T polymorphism was significantly associated with a decreased RA risk in an Asian population.
|
25179669 |
2014 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis demonstrated that PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms confers susceptibility to RA in total subjects and in major ethnic groups.
|
25963842 |
2015 |