|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated whether a single nucleotide polymorphism (SNP) of the STAT4 (rs7574865), PTPN22 (rs2476601), TRAF1/C5 (rs10818488), and C1q (rs292001) genes as well as the 27-bp VNTR polymorphism on intron 4 of eNOS, previously associated with SLE in other populations, are also associated with SLE risk in Turkey.
|
21968398 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We decided to investigate the association of single-nucleotide polymorphisms (SNPs) in the IRF7/KIAA1542 region (rs4963128, rs2246614, and rs702966) and in STAT4 (rs7574865 and rs7582694) with SLE disease in a Northern Han Chinese population of 748 patients and 750 healthy controls.
|
21167895 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We concluded that STAT4 rs7574865 is associated with SLE susceptibility in the Iranian population and this SNP might be a factor in the pathogenesis of SL</span>E.
|
23912645 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We aimed to analyze three SNPs located in the <i>STAT4</i> (rs7574865), <i>ITGAM</i> (rs1143679) and <i>TNXB</i> (rs1150754) genes in both DLE and SLE patients from Poland.
|
28670251 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To test the hypothesis that the variant haplotype of STAT4 seen in RA and SLE is also associated with pSS, we genotyped rs7574865, the most strongly disease-associated SNP in the variant STAT4 haplotype, in 124 Caucasian pSS subjects and compared them to 1143 Caucasian controls.
|
18273036 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Thus, the STAT4 rs7574865G/T polymorphism confers risk for RA and SLE in the Mexican population.
|
27178308 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates that the STAT4 rs7574865 T allele confers susceptibility to SLE, RA, T1D, SSc, JIA, APS, IBD-UC, and pSS patients, supporting the hypothesis of association between STAT4 gene polymorphism and subgroup of autoimmune diseases.
|
22714917 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The TT genotype of STAT4 rs7574865 was significantly associated with increased risk of SLE (OR 2.21, 95% CI 1.10-4.68).
|
19684152 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs7574865 in STAT4 is strongly associated with risk of SLE in the Chinese Northern Han population.
|
21163111 |
2010 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The risk variant of STAT4 (T allele; rs7574865) was simultaneously associated with both lower serum IFN-alpha activity and greater IFN-alpha-induced gene expression in PBMC in SLE patients in vivo.
|
19109131 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results of our meta-analysis demonstrated that STAT4 rs7574865 SNP is significantly associated with RA and SLE.
|
19479340 |
2010 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The haplotype marked by rs7574865 was strongly associated with lupus, being present on 31% of chromosomes of case patients and 22% of those of controls (P=1.87x10(-9); odds ratio for having the risk allele in chromosomes of patients vs. those of controls, 1.55).
|
17804842 |
2007 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
STAT4 polymorphism, rs7574865 is linked to various autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
|
27960128 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
SNP rs7574865 marking this haplotype had a minor allele frequency (MAF) = 31.1% in SLE cases compared with 22.5% in controls (OR = 1.56, p = 10(-16)).
|
18516230 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the association of a STAT4 haplotype marked by rs7574865 with rheumatoid arthritis (RA) and systemic lupus erythematosus was reported.
|
18759272 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis revealed that the STAT4 rs7574865 polymorphism is associated with four autoimmune diseases with systemic pathology, including systemic lupus erythematosus (OR = 1.52; 95% CI = 1.48 - 1.56, P<1.0 × 10(-16)), rheumatoid arthritis (OR = 1.27; 95% CI = 1.21 - 1.33, P < 1.00 × 10(-16)), systemic sclerosis (OR = 1.38; 95% CI = 1.27 - 1.50, P < 1.44 × 10(-14)), and primary Sjogren's syndrome (OR = 1.32; 95% CI = 1.01 - 1.73, P = 4.40 × 10(-2)), while no association was found with type I diabetes, juvenile idiopathic arthritis, ulcerative colitis and Crohn's disease.
|
23628400 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.
|
18432273 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 x 10(-23)) and BLK (rs13277113, OR=0.77, P=1.34 x 10(-5)) with SLE.
|
19225526 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
MDR analysis revealed significant gene-gene interactions among glutathione-S-transferase (GST)T1 and STAT4 (rs3821236 and rs7574865) polymorphisms, which account for moderate predictability of SLE.
|
26689915 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, our results do support STAT4 rs7574865 polymorphism as a susceptibility factor for SLE in populations of European and Asian origin.
|
20169389 |
2010 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
|
23053960 |
2012 |