rs7574865, STAT4

N. diseases: 59
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.050 GeneticVariation BEFREE Genomic DNA from 288 cases with chronic HBV infection and 288 controls who spontaneously recovered from HBV infection was analyzed for five SNPs in the STAT4 gene (rs7574865, rs7572482, rs7582694 rs11889341, and rs8179673).Our analysis revealed that all the minor alleles of the four SNPs (rs7574865, rs7582694, rs11889341, and rs8179673) had an association with overall decreased risk to HBV infection [p = 0.040, OR 0.762 (95 % CI 0.593-0.981); p = 0.011, OR 0.686 (95 % CI 0.535-0.878); p = 0.023, OR 0.751 (95 % CI 0.586-0.962); p = 0.002, OR 0.670 (95 % CI 0.521-0.861), respectively]. 25829184 2015
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.050 GeneticVariation BEFREE In a retrospective analysis of data from 4 clinical trials, we found rs7574865 in STAT4 to be associated with functional cure of chronic HBV infection by PegIFN treatment, but not NUCs treatment, in HBeAg-positive patients with HBV genotype B infection. 31042581 2020
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.050 GeneticVariation BEFREE The present study also indicates that <i>STAT4</i> rs7574865 polymorphism increased the risk of chronic HBV infection and HCC. 31160486 2019
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.050 GeneticVariation BEFREE SNP rs7574865 was significantly associated with HBV infection [odds ratio (OR) 1.15; 95 % confidence interval (CI) 1.00, 1.31; P = 0.046] and clearance (OR 1.17; 95 % CI 1.02, 1.33; P = 0.028). 27444301 2016
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.050 GeneticVariation BEFREE A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population. 25913043 2015