rs7574865, STAT4

N. diseases: 59
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE Recent studies have indicated associations of rs7574865 single nucleotide polymorphism (SNP) in the STAT4 gene with various autoimmune diseases. 27126090 2017
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE STAT4 polymorphism, rs7574865 is linked to various autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. 27960128 2017
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. 26569609 2015
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE This meta-analysis demonstrates that the STAT4 rs7574865 T allele confers susceptibility to SLE, RA, T1D, SSc, JIA, APS, IBD-UC, and pSS patients, supporting the hypothesis of association between STAT4 gene polymorphism and subgroup of autoimmune diseases. 22714917 2012
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation GWASDB Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. 21383967 2011
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. 21383967 2011
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE Taking into consideration that the different autoimmune diseases may share some common pathogenetic pathways, the aim of the present study was to evaluate the role of STAT4 rs7574865 polymorphism on acute allograft rejection. 21237270 2011
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE But, no significant differences in allele and genotype frequencies of STAT4 rs7574865 polymorphism were detected according to the presence of another autoimmune disease, nodules and in HLA-DRB1*04 and HLA-DRB1*0404 positive subgroups. 21418779 2011
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE We recently reported for the first time as a PS-associated SNP the signal transducer and activator of transcription-4 (STAT4) rs7574865 polymorphism, which is also associated with several autoimmune diseases. 20039785 2010
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE We found that mutated allele T of the STAT4 rs7574865 SNP, which previously was implicated in the predisposition to many autoimmune diseases, were more common in individuals with psoriasis than in controls (p = 0.045, odds ratio = 1.42, 95% confidence interval 1.01-2.00), thus concluding that the polymorphism examined is associated with the development of psoriasis in our population. 19500629 2009
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases. 18432273 2008
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.900 GeneticVariation BEFREE Here we demonstrate for the first time, in a genetically homogeneous population, the association of the STAT4 rs7574865 G/T polymorphism, which has been shown to be associated with these autoimmune diseases, with susceptibility to type 1 diabetes (T1D). 18703106 2008