rs7574865, STAT4

N. diseases: 59
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.050 GeneticVariation BEFREE No association was detected between rs7574865 polymorphism and CD susceptibility in overall, Asian and Caucasian population, respectively. 26066297 2015
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.050 GeneticVariation BEFREE Three PBC susceptibility genes, CXCR5 rs6421571, STAT4 rs7574865 and NFKB1 rs230534, were nominally associated with susceptibility to CD (P=2.82 × 10(-2), P=3.88 × 10(-2) and P=2.04 × 10(-2), respectively). 26084578 2015
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.050 GeneticVariation BEFREE Our meta-analysis revealed that the STAT4 rs7574865 polymorphism is associated with four autoimmune diseases with systemic pathology, including systemic lupus erythematosus (OR = 1.52; 95% CI = 1.48 - 1.56, P<1.0 × 10(-16)), rheumatoid arthritis (OR = 1.27; 95% CI = 1.21 - 1.33, P < 1.00 × 10(-16)), systemic sclerosis (OR = 1.38; 95% CI = 1.27 - 1.50, P < 1.44 × 10(-14)), and primary Sjogren's syndrome (OR = 1.32; 95% CI = 1.01 - 1.73, P = 4.40 × 10(-2)), while no association was found with type I diabetes, juvenile idiopathic arthritis, ulcerative colitis and Crohn's disease. 23628400 2013
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.050 GeneticVariation BEFREE However, the meta-analysis showed that the STAT4 rs7574865 T allele was significantly associated with susceptibility to UC (p = 0.012 pooled; OR = 1.20, 95% CI = 1.04-1.39) but not CD (p = 0.71 pooled; OR = 0.93, 95% CI = 0.65-1.34). 20153791 2010
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.050 GeneticVariation BEFREE Our results identified the STAT4 SNP rs7574865 as a disease-modifying gene variant in colonic CD. 20454450 2010