rs7574865, STAT4

N. diseases: 59
Disease: Polyendocrinopathies, Autoimmune ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Polyendocrinopathies, Autoimmune
CUI: C0085409
Disease: Polyendocrinopathies, Autoimmune
0.020 GeneticVariation BEFREE The overall odds ratios for rs7574865 T-allele significantly increased in SLE, RA, T1D, SSc, JIA, and APS (OR = 1.56, 1.25, 1.13, 1.34, 1.25, and 2.15, respectively, P < 0.00001) and in IBD-UC and pSS (OR = 1.11 and 1.33, respectively, P < 0.05). 22714917 2012
Polyendocrinopathies, Autoimmune
CUI: C0085409
Disease: Polyendocrinopathies, Autoimmune
0.020 GeneticVariation BEFREE STAT4 and BLK displayed a strong genetic association with primary APS (for rs7574865, odds ratio [OR] 2.19, P=5.17x10(-7); for rs2736340, OR 2.06, P=1.78x10(-6)), while a weak association with IRF5 and no association with BANK1 were observed. 19644876 2009