rs7574865, STAT4

N. diseases: 59
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE In contrast, STAT4-rs7574865 was associated with HCC only in HBV infected patients (p = 0.03) and the other tested SNP were not linked with HCC risk. 30289982 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE The present study also indicates that <i>STAT4</i> rs7574865 polymorphism increased the risk of chronic HBV infection and HCC. 31160486 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE We identified that <i>STAT4</i>-rs7574865 polymorphism was significantly associated with an increased risk of HCC in allelic contrast, dominant, homozygote and recessive models. 30310516 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE A significantly increased risk of HCC associated with the rs7574865 G was found. 27126090 2017
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE We observed that the STAT4 (2q32.2-q32.3) at rs7574865 (P=1.17×10(-3), OR=0.79) and EFCAB11 (14q32.11) at rs8013403 (P=1.54×10(-3), OR=0.80) were significantly associated with HCC in this study. 25665738 2015
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population. 25913043 2015
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Of the 12 SNPs reported in HBV-related HCC GWASs, five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC (rs7574865: P = 1.79 × 10(-2), OR = 1.17, 95% CI = 1.03-1.34; rs9267673: P = 4.91 × 10(-4), OR = 1.37, 95% CI = 1.15-1.63; rs2647073: P = 3.53 × 10(-5), OR = 1.63, 95% CI = 1.29-2.06; rs3997872: P = 4.22 × 10(-4), OR = 1.86, 95% CI = 1.32-2.62; rs9275319: P = 1.30 × 10(-2), OR = 1.32, 95% CI = 1.06-1.64). 26538132 2015
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Our data demonstrated positive association of rs7574865 with HCC risk when compared to healthy controls under an additive model (GG versus TT: odds ratio (OR) =2.07, 95% confidence interval (CI)=1.06-4.03, P=0.033). 26745093 2015
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Moreover, current data failed to acquire positive connection of rs7574865 with HCC development (experiment, OR = 0.86, 95%CI = 0.62-1.19; meta-analysis, OR = 0.87, 95%CI = 0.74-1.03), which may be due to the small sample size. 25365208 2014
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation GWASDB The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively). 23242368 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation GWASCAT The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively). 23242368 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively). 23242368 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE The STAT4 variant (rs7574865) was marginally associated with HCC susceptibility in CHB carriers in allelic and recessive genetic models (OR=0.84, 95%CI=0.7-0.99, P=0.048 and OR=0.7, 95%CI=0.5-0.99, P=0.047). 23748017 2013