|
Lupus Erythematosus, Systemic
|
|
0.740 |
GeneticVariation
|
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.740 |
GeneticVariation
|
GWASCAT |
Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry.
|
26316170 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.740 |
GeneticVariation
|
BEFREE |
Our studies confirmed an association of the STAT4 C (rs7582694) variant with the development of SLE and occurrence of some clinical manifestations of the disease.
|
22729903 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.740 |
GeneticVariation
|
BEFREE |
The results of our study demonstrated that STAT4 rs7582694 SNP was significantly associated with SLE, and these results were in accordance with previous studies.
|
21258797 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.740 |
GeneticVariation
|
BEFREE |
We decided to investigate the association of single-nucleotide polymorphisms (SNPs) in the IRF7/KIAA1542 region (rs4963128, rs2246614, and rs702966) and in STAT4 (rs7574865 and rs7582694) with SLE disease in a Northern Han Chinese population of 748 patients and 750 healthy controls.
|
21167895 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.740 |
GeneticVariation
|
BEFREE |
The risk allele of the SNP rs7582694 in STAT4 correlated to production of anti-dsDNA (double-stranded DNA) antibodies and displayed a multiplicatively increased, 1.82-fold risk of SLE with two independent risk alleles of the IRF5 (interferon regulatory factor 5) gene.
|
18579578 |
2008 |
|
Hypothyroidism
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Endometriosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study's aim is to evaluate the possible association between four STAT4 polymorphisms (rs7601754/G > A, rs11889341/C > T, rs7574865/T > G, and rs7582694/C > G) and the pathogenesis of endometriosis in Brazilian women.
|
30887509 |
2019 |
|
Endometriosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results for the first time showed a significant association between rs7582694 alleles and genotypes and susceptibility to endometriosis in a population.
|
27235632 |
2016 |
|
Autoimmune Chronic Hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk.
|
28977835 |
2017 |
|
Autoimmune hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk.
|
28977835 |
2017 |
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genomic DNA from 288 cases with chronic HBV infection and 288 controls who spontaneously recovered from HBV infection was analyzed for five SNPs in the STAT4 gene (rs7574865, rs7572482, rs7582694 rs11889341, and rs8179673).Our analysis revealed that all the minor alleles of the four SNPs (rs7574865, rs7582694, rs11889341, and rs8179673) had an association with overall decreased risk to HBV infection [p = 0.040, OR 0.762 (95 % CI 0.593-0.981); p = 0.011, OR 0.686 (95 % CI 0.535-0.878); p = 0.023, OR 0.751 (95 % CI 0.586-0.962); p = 0.002, OR 0.670 (95 % CI 0.521-0.861), respectively].
|
25829184 |
2015 |
|
Kidney Failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the case-only meta-analysis of the two cohorts, the STAT4 SNP rs7582694 was associated with severe renal insufficiency with p = 1.6 × 10(-3) and OR 2.22.
|
24386384 |
2013 |
|
Renal Insufficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the case-only meta-analysis of the two cohorts, the STAT4 SNP rs7582694 was associated with severe renal insufficiency with p = 1.6 × 10(-3) and OR 2.22.
|
24386384 |
2013 |
|
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
STAT4 rs7582694 C allele was associated with pSS in both cohorts (odds ratio (OR) 1.57, 95% confidence interval (CI) 1.27-1.93, P=2.3 x 10(-5)).
|
20535138 |
2010 |