|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum.
|
29785763 |
2019 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to develop a simple, fast and accurate new method for detecting the Val66Met polymorphism of the BDNF gene in schizophrenia patients using melting-curve analysis and a DNA-specific dye, SYBR Green I.
|
19530966 |
2009 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment.
|
12951204 |
2003 |
|
Mood Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism.
|
15719396 |
2005 |
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested no genetic association of BDNF Val66Met with vulnerability to PTSD.
|
25925851 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024).
|
18450378 |
2008 |
|
Drug abuse
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant four-way interactions were found for BDNF Val66Met × 5-HTTLPR×MAOA-uVNTR × family conflicts and for BDNF Val66Met × 5-HTTLPR×MAOA-uVNTR × sexual abuse.
|
25522433 |
2014 |
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms.
|
27852165 |
2017 |
|
Anxiety
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.
|
19582565 |
2009 |
|
Anxiety
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety.
|
26119141 |
2015 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history.
|
23880378 |
2013 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine, by meta-analysis, if the Val66Met polymorphism of BDNF influences risk for either schizophrenia, bipolar disorder, or both.
|
17417060 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, in a meta-analysis, the Val66Met polymorphism was not associated with schizophrenia, whereas C270T showed a trend for association in a fixed model (p=0.036), but not in a random model (p=0.053).
|
19406621 |
2009 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment.
|
23769397 |
2013 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism may modify the association between stroke and depression.
|
17222482 |
2008 |
|
Obsessive-Compulsive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Findings from this meta-analytic investigation of published literature provide little support for the Val66Met variant of BDNF as a predictor of OCD.
|
31291217 |
2019 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.
|
20220593 |
2010 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) is associated with psychiatric disorders and regional gray matter volume (rGMV) in adults.
|
26830347 |
2016 |
|
Psychotic Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome.
|
31822818 |
2019 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis.
|
25539739 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a family-based association study and ETDT analyses of the Val66Met polymorphism in 312 BD nuclear families, and compared allele-specific mRNA levels in both post-mortem brain samples and B lymphoblasts from BD patients and controls.
|
18606495 |
2008 |
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the BDNF Val66Met polymorphism.
|
30659208 |
2019 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity.
|
18721847 |
2008 |