Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. 15770238 2005
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder. 15913870 2005
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE No significant association was found between BDNF Val66Met polymorphism and AD [OR = 1.13 (95% CI: 0.85-1.52) for Met/Met versus Val/Val] or HA [SMD = 0.11 (95% CI: -0.19, 0.42) for Met/Met vs. Val/Val]. 19088493 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. 19153574 2009
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. 19582565 2009
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function. 19931400 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE A common polymorphism of the brain-derived neurotrophic factor (BDNF) gene (Val66Met) has been implicated in anxiety, which is associated with lower vagal activity. 20213725 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans. 20478625 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders. 20515664 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE In line with recent studies investigating the role of BDNF Val66Met and DRD2/ANKK1 Taq IA polymorphisms on anxiety and gray matter volume in the ACC, our findings provide the first evidence for a genetic contribution to alexithymia. 21097659 2011
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults. 21596481 2011
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Our results support the a priori hypothesis of an association between anxiety and the polymorphism Val66Met. 21839144 2011
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes. 23026378 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Gender-specific effects of brain-derived neurotrophic factor Val66Met polymorphism and childhood maltreatment on anxiety. 23221871 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism? 23357445 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. 24021960 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE In this work, we review the literature focused on the BDNF Val(66)Met polymorphism and anxiety, and discuss biological findings from animal models to clinical studies. 24051499 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder. 26037856 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Patients with depressive or anxiety disorders and with available BDNF Val(66)Met polymorphism data (N=1271) were selected from Netherlands Study of Depression and Anxiety (NESDA). 25618300 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. 25640836 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders. 25824305 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety. 26119141 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE On the contrary, BDNF met allele carriers showed a reduced acoustic startle response which reached significance in most samples (N1: p=0.004; N2: p=0.045; N3: n.s., N4: p=0.043) pointing to differential effects of BDNF val(66)met on distinct endophenotypes of anxiety and stress-related responses. 26773399 2016