Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. 30078664 2019
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The BDNF Val66Met gene polymorphism is associated with increased alexithymic and anticipatory anxiety in patients with panic disorder. 30269521 2019
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Interactive genetic association with anxiety was observed such that effects of 5-HTTLPR depended on the BDNF Val66Met polymorphism (rs6265 variant), with higher anxiety scores in short and Met carriers compared to the other allelic groups. 30711709 2019
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The aim of the present case-control study was to explore the association between BDNF Val66Met (rs6265) polymorphism and generalized anxiety disorder in Mexican individuals, and whether this polymorphism plays a role in the symptomatology of anxiety.A total of 212 subjects were included in the study. 30882674 2019
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice. 29084453 2017
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE On the contrary, BDNF met allele carriers showed a reduced acoustic startle response which reached significance in most samples (N1: p=0.004; N2: p=0.045; N3: n.s., N4: p=0.043) pointing to differential effects of BDNF val(66)met on distinct endophenotypes of anxiety and stress-related responses. 26773399 2016
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Patients with depressive or anxiety disorders and with available BDNF Val(66)Met polymorphism data (N=1271) were selected from Netherlands Study of Depression and Anxiety (NESDA). 25618300 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. 25640836 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders. 25824305 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety. 26119141 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder. 26037856 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes. 23026378 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Gender-specific effects of brain-derived neurotrophic factor Val66Met polymorphism and childhood maltreatment on anxiety. 23221871 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism? 23357445 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. 24021960 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE In this work, we review the literature focused on the BDNF Val(66)Met polymorphism and anxiety, and discuss biological findings from animal models to clinical studies. 24051499 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE In line with recent studies investigating the role of BDNF Val66Met and DRD2/ANKK1 Taq IA polymorphisms on anxiety and gray matter volume in the ACC, our findings provide the first evidence for a genetic contribution to alexithymia. 21097659 2011
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults. 21596481 2011
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Our results support the a priori hypothesis of an association between anxiety and the polymorphism Val66Met. 21839144 2011
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function. 19931400 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE A common polymorphism of the brain-derived neurotrophic factor (BDNF) gene (Val66Met) has been implicated in anxiety, which is associated with lower vagal activity. 20213725 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans. 20478625 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders. 20515664 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. 19153574 2009