Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects.
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15770238 |
2005 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder.
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15913870 |
2005 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
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17941097 |
2008 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
No significant association was found between BDNF Val66Met polymorphism and AD [OR = 1.13 (95% CI: 0.85-1.52) for Met/Met versus Val/Val] or HA [SMD = 0.11 (95% CI: -0.19, 0.42) for Met/Met vs. Val/Val].
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19088493 |
2008 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.
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19153574 |
2009 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.
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19582565 |
2009 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders.
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20515664 |
2010 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
A common polymorphism of the brain-derived neurotrophic factor (BDNF) gene (Val66Met) has been implicated in anxiety, which is associated with lower vagal activity.
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20213725 |
2010 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function.
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19931400 |
2010 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans.
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20478625 |
2010 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Our results support the a priori hypothesis of an association between anxiety and the polymorphism Val66Met.
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21839144 |
2011 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
In line with recent studies investigating the role of BDNF Val66Met and DRD2/ANKK1 Taq IA polymorphisms on anxiety and gray matter volume in the ACC, our findings provide the first evidence for a genetic contribution to alexithymia.
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21097659 |
2011 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults.
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21596481 |
2011 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes.
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23026378 |
2013 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
In this work, we review the literature focused on the BDNF Val(66)Met polymorphism and anxiety, and discuss biological findings from animal models to clinical studies.
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24051499 |
2013 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD.
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24021960 |
2013 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Gender-specific effects of brain-derived neurotrophic factor Val66Met polymorphism and childhood maltreatment on anxiety.
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23221871 |
2013 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism?
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23357445 |
2013 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder.
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26037856 |
2014 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety.
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26119141 |
2015 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders.
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25824305 |
2015 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes.
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25640836 |
2015 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
Patients with depressive or anxiety disorders and with available BDNF Val(66)Met polymorphism data (N=1271) were selected from Netherlands Study of Depression and Anxiety (NESDA).
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25618300 |
2015 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D.
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25498133 |
2015 |
Anxiety Disorders
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0.100 |
GeneticVariation
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BEFREE |
On the contrary, BDNF met allele carriers showed a reduced acoustic startle response which reached significance in most samples (N1: p=0.004; N2: p=0.045; N3: n.s., N4: p=0.043) pointing to differential effects of BDNF val(66)met on distinct endophenotypes of anxiety and stress-related responses.
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26773399 |
2016 |