Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). 29896439 2018
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE The BDNF-Val66Met-polymorphism leads to altered intracellular transport and secretion of BDNF, and is thus a logical candidate for a gene that influences susceptibility and, more specifically, the clinical course of multiple sclerosis. 16046000 2005
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE The Val(66)Met polymorphism has opposite effects on hippocampal circuitry underlying episodic memory in Multiple Sclerosis patients and healthy controls. 23593393 2013
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE To investigate the association of the rs6265 (Val66Met) single nucleotide polymorphism (SNP) of brain-derived neurotrophic factor (BDNF) with brain morphometry and functional status as measured by quantitative magnetic resonance imaging (MRI) and neurocognitive testing in multiple sclerosis (MS) patients. 17656372 2007
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE Brain-Derived Neurotrophic Factor (BDNF) and its most common polymorphism Val66Met are known to have a role in Multiple Sclerosis (MS) pathogenesis. 30352103 2018
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE Our imaging genetic study demonstrates that the Val(66)Met polymorphism of the BDNF gene contributes to some of the individual variability in the functional response to a working memory challenge in healthy controls but it does not provide evidence for an MS-specific pattern of gene action. 19874854 2010
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE BDNF A196G and C270T gene polymorphisms and susceptibility to multiple sclerosis in the Polish population. Gender differences. 18061279 2008
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE Depression in multiple sclerosis: effect of brain derived neurotrophic factor Val66Met polymorphism and disease perception. 26756166 2016
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism and brain volumes in multiple sclerosis. 20953813 2011
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.100 GeneticVariation BEFREE Therefore, we investigated the impact of the BDNF-Val66Met polymorphism on the susceptibility and clinical course in a case-control study of 224 multiple sclerosis (MS) Spanish patients and 177 healthy controls. 16356643 2006