|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Fifty-two samples from the depressed patient group were genotyped for the Val66Met BDNF polymorphism.
|
29802070 |
2019 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC.
|
30904785 |
2019 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF.
|
29280414 |
2019 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
|
29535036 |
2019 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect.
|
29102837 |
2018 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to examine the chronic stress × BDNF Val66Met</span> interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet.
|
29734099 |
2018 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
|
29331787 |
2018 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression.
|
27073970 |
2017 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val66Met in the modulation of stress reactivity and subsequent depression prevalence.
|
28249185 |
2017 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms.
|
27852165 |
2017 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
|
28527683 |
2017 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models.
|
26795846 |
2016 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study.
|
26976307 |
2016 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
|
26756166 |
2016 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression.
|
26462036 |
2015 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression.
|
25648279 |
2015 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
|
26393465 |
2015 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety.
|
25618300 |
2015 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
|
25745134 |
2015 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no interaction between depression and Val66Met genotype status.
|
25188405 |
2014 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03).
|
24433458 |
2014 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history.
|
25347540 |
2014 |