|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD).
|
31308724 |
2019 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism.
|
28656803 |
2018 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide.
|
29432620 |
2018 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers.
|
29778546 |
2018 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant effect of the interaction of the BDNF Val66Met polymorphism and MDD on the fractional anisotropy values of the right uncinate fasciculus was observed.
|
29414128 |
2018 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels.
|
28848102 |
2017 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, we did not detect any plausible evidence regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD.
|
29387021 |
2017 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population.
|
27212180 |
2016 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response.
|
26976307 |
2016 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD.
|
26078197 |
2015 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.
|
25745134 |
2015 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls.
|
26117067 |
2015 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD.
|
25510949 |
2015 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in MDD compared to healthy controls and which subfields are affected by the BDNF Val</span>66Met</span> polymorphism and child adversity.
|
25044977 |
2014 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our two-center study was to determine how the BDNF Val66Met</span> polymorphism and childhood adversity affect the volumetric measures of the hippocampus in healthy individuals and people with MDD.
|
23341118 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting.
|
23184535 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three polymorphisms in the BDNF gene (rs7103411, rs6265 (Val66Met) and rs7124442) were genotyped in 324 patients with MDD and 470 healthy controls.
|
22965830 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to evaluate the association of regional gray matter (GM) volume within the hippocampus and other unpredicted regions at the whole-brain level with the BDNF Val66Met polymorphism in MDD patients with melancholic features and their impact on treatment outcome.
|
23165919 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant associations between AD and MDD have been found for three polymorphisms mainly in females (TPH1 A218C, MAOA VNTR and BDNF Val66Met) and one polymorphism in the total population only (FKBP5 rs1360780).
|
23157339 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD.
|
22883353 |
2012 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype.
|
22585743 |
2012 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found no significant association of either the BDNF G196A or MTHFR C677T polymorphisms with major depressive disorder neither in female nor male group of patients.
|
23255668 |
2012 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent meta-analyses point towards a pathogenic role of the Val66Met variant of the brain-derived neurotrophic factor (BDNF) in major depressive disorder, specifically in males.
|
22033217 |
2012 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia.
|
21129438 |
2011 |