rs763361, CD226

N. diseases: 21
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE These findings revealed that CD226 rs763361 polymorphism was significantly associated with susceptibility to T1D and that the presence of the T allele might be a genetic factor for susceptibility to T1D. 26634488 2015
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE The rs763361 variant of CD226 gene (TT genotype) was associated with susceptibility to T1D and with the degree of aggressiveness of the disease in T1D patients from Brazil.Ancestry had no effect. 24891767 2014
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS). 23073294 2013
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D. 22941566 2012
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population. 21765104 2011
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation GWASCAT Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. 21829393 2011
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE The current study supports the rs6679677 (PHTF1-PTPN22), rs17696736 (C12orf30) and rs763361 (CD226) SNPs as susceptibility factors for type 1 diabetes outside the major histocompatibility region (MHC) region. 20089178 2010
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46 x 10(-9) (OR = 1.14), respectively. 20338887 2010
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017). 18971939 2009
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. 19624611 2009
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation BEFREE Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease. 19536154 2009
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation GWASCAT Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. 17554260 2007
Diabetes Mellitus, Insulin-Dependent
0.900 GeneticVariation GWASDB Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. 17554260 2007
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.770 GeneticVariation BEFREE The goal of the current study was to investigate the association of single nucleotide polymorphisms (SNP) with the immunologically related genes responsible for the disease, composed of CD58 (rs2300747 A>G), CD226 (rs763361 C>T), and HLA-G (rs1611715 A>C), with MS susceptibility. 30128676 2018
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.770 GeneticVariation BEFREE Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS). 23073294 2013
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.770 GeneticVariation GWASDB Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. 22190364 2011
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.770 GeneticVariation BEFREE Two other SNPs were nominally associated with MS in this dataset, namely CLEC16A rs 12708716 (p = 0.0082, OR = 1.478, 95% CI = 1.106-1.975) and CD226 rs763361 (p = 0.03971, OR = 1.353, CI = 1.014-1.805). 20952449 2011
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.770 GeneticVariation BEFREE We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population. 21765104 2011
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.770 GeneticVariation BEFREE Three SNPs were found to be associated with MS: rs1678542 in KIF5A (P=0.001, odds ratio (OR)=1.13, 95% confidence interval (CI)=1.05-1.23); rs3184504 in SH2B3 (P=0.00001, OR=1.19, 95% CI=1.10-1.27) and rs763361 in CD226 (P=0.00007, OR=1.16, 95%CI=1.08-1.25). 20508602 2010
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.770 GeneticVariation BEFREE Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients. 19536154 2009
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.770 GeneticVariation BEFREE In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017). 18971939 2009
Primary sclerosing cholangitis
CUI: C0566602
Disease: Primary sclerosing cholangitis
0.700 GeneticVariation GWASDB Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. 23603763 2013
Autoantibody measurement
CUI: C1272321
Disease: Autoantibody measurement
0.700 GeneticVariation GWASDB Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. 21829393 2011
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.090 GeneticVariation BEFREE Moreover, co-engagement of the TCR and a risk variant of CD226 that is associated with autoimmunity (rs763361) further enhanced VAV1 activation and IL-17 production. 29991650 2018
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.090 GeneticVariation BEFREE This meta-analysis provided evidence that CD226 Gly307Ser (rs763361) is significantly associated with the risk of multiple autoimmune diseases. 23073294 2013