| Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | Our results suggest that the RFC-1 80G>A (rs1051266) SNP exerts a potentially protective effect against the risk of adverse drug reactions in Chinese RA patients treated with MTX. | 31099054 | 2019 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | In multivariate analysis, patients with the solute carrier family 19 member 1 (SLC19A1) 80G>A A/A genotype had a better response than those with the A/G or G/G genotype, and patients with the C allele of γ-glutamyl hydrolase (GGH) 16T>C had a better response than those with the T/T genotype.This study showed that the therapeutic response to MTX in Japanese RA patients was associated with the genetic polymorphisms of SLC19A1 80G>A and GGH 16T>C in actual clinical practice. | 30175777 | 2018 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | RFC-1 80G > A gene polymorphism confers protection for RA. | 25771854 | 2016 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | In conclusion, the RFC1 G80A polymorphism is associated with responsiveness to MTX therapy, but may not be associated with MTX toxicity in RA patients. | 27233001 | 2016 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | The aim of our study was to characterize the association of clinicopathological variables and the SLC19A1/RFC-1 G80A polymorphism in methotrexate (MTX)-related toxicity in Portuguese patients with rheumatoid arthritis. | 24350725 | 2014 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | In these analyses of available data from observational studies, RFC1 80G>A was found to be associated with MTX efficacy, but not toxicity, in RA patients. | 24782176 | 2014 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | The results of this study suggest that the RFC1 G80A polymorphism may be a useful marker for predicting MTX efficacy in Japanese patients with RA. | 22971639 | 2013 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | Frequencies of MTHFR C677T and A1298C were similar to those reported in Japanese RA patients, while frequencies of RFC-1 G80A genotypes differed from those reported in RA patients in the United States. | 17965559 | 2007 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | The present data suggest that evaluation of RFC-1 gene 80G>A polymorphism may be a useful tool to optimize MTX therapy in patients with RA. | 17325736 | 2007 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | We investigated the contribution of common genetic polymorphisms in RFC-1 (G80A), ATIC (C347G), and TS (28-bp tandem repeats located in the TS enhancer region [TSER*2/*3]) and of MTXPGs to the effect of MTX in patients with rheumatoid arthritis. | 15457444 | 2004 | |||||
Rheumatoid Arthritis
|
0.100 | GeneticVariation | BEFREE | We investigated whether polymorphisms in reduced folate carrier (SLC19A1 G80A) and gamma-glutamyl-hydrolase (GGH-401C/T) are predictive of methotrexate polyglutamate (MTXPG) levels in patients with rheumatoid arthritis treated with weekly low-dose methotrexate (MTX). | 15564880 | 2004 |