|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.080 |
GeneticVariation
|
BEFREE |
rs5219 (E23K) in KCNJ11 was associated with genetic susceptibility to type 2 diabetes (OR = 1.400 with 95% CI 1.117 1.755, P = 0.004 under an additive model, OR = 1.652 with 95% CI 1.086 2.513, P = 0.019 under a recessive model, and OR = 1.521 with 95% CI 1.089 2.123, P = 0.014 under a dominant model) after adjusting for sex and body mass index (BMI).
|
20079163 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.080 |
GeneticVariation
|
BEFREE |
The P12A variant in the PPARG gene and the E23K polymorphism in KCNJ11 are both known to influence individual predisposition to type 2 diabetes.
|
17994213 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.080 |
GeneticVariation
|
BEFREE |
These variants may contribute significantly to the risk type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys).
|
15715885 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes.
|
15797964 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.080 |
GeneticVariation
|
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.080 |
GeneticVariation
|
BEFREE |
We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2).
|
14988278 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.080 |
GeneticVariation
|
BEFREE |
In contrast, the well-documented associations of peroxisome proliferator-activated receptor gamma P12A and Kir6.2 E23K with type 2 diabetes are both robustly observed in these 9,000 subjects, including an additional (previously unpublished) confirmation of Kir6.2 E23K and type 2 diabetes in the Polish and North American samples (combined OR 1.15 [1.05-1.26], P = 0.001).
|
15561965 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.080 |
GeneticVariation
|
BEFREE |
We show that E23K is also associated with decreased insulin secretion in glucose-tolerant control subjects, supporting a mechanism whereby beta-cell dysfunction contributes to the common form of type 2 diabetes.
|
15111507 |
2004 |