|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01).
|
18008060 |
2008 |
|
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01).
|
18008060 |
2008 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
|
18179892 |
2008 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
|
18179892 |
2008 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
|
18179892 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
18193043 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
18193043 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
18193044 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
18193044 |
2008 |
|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|
18439548 |
2008 |
|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|
18439548 |
2008 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|
19060911 |
2009 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|
19060911 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals.
|
19241058 |
2009 |
|
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
The GCKR rs780094 was also associated with obesity and BMI, independently of its association with type 2 diabetes.
|
19241058 |
2009 |
|
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals.
|
19241058 |
2009 |
|
Uric acid measurement (procedure)
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
|
19503597 |
2009 |
|
Uric acid measurement (procedure)
|
|
0.800 |
GeneticVariation
|
GWASDB |
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
|
19503597 |
2009 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
20081858 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
This suggests that GCKR rs7</span>80094 is a common variant for T</span>2DM susceptibility in various ethnic groups.
|
20574426 |
2010 |
|
Hypertriglyceridemia
|
|
0.730 |
GeneticVariation
|
BEFREE |
The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population.
|
20574426 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.790 |
GeneticVariation
|
BEFREE |
Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people.
|
20625834 |
2011 |