|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01).
|
18008060 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
18193044 |
2008 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
|
18179892 |
2008 |
|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|
18439548 |
2008 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
|
18179892 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
18193043 |
2008 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|
18439548 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
18193043 |
2008 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
18193044 |
2008 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
|
18179892 |
2008 |
|
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01).
|
18008060 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals.
|
19241058 |
2009 |
|
Uric acid measurement (procedure)
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
|
19503597 |
2009 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|
19060911 |
2009 |
|
Uric acid measurement (procedure)
|
|
0.800 |
GeneticVariation
|
GWASDB |
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
|
19503597 |
2009 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|
19060911 |
2009 |
|
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
The GCKR rs780094 was also associated with obesity and BMI, independently of its association with type 2 diabetes.
|
19241058 |
2009 |
|
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals.
|
19241058 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
This suggests that GCKR rs7</span>80094 is a common variant for T</span>2DM susceptibility in various ethnic groups.
|
20574426 |
2010 |
|
Metabolic Syndrome X
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations.
|
21114848 |
2010 |
|
Coronary heart disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
Our findings indicate rs780094 has independent associations with multiple metabolic traits as well as incident diabetes, but not incident CHD or stroke.
|
20661421 |
2010 |
|
Arthritis, Gouty
|
|
0.800 |
GeneticVariation
|
GWASDB |
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
|
20884846 |
2010 |