rs780094, GCKR

N. diseases: 62
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Glomerular Filtration Rate
CUI: C0017654
Disease: Glomerular Filtration Rate
0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.730 GeneticVariation GWASCAT A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. 27599772 2017
Body mass index
CUI: C1305855
Disease: Body mass index
0.800 GeneticVariation GWASDB A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
Fasting blood glucose measurement
CUI: C0428568
Disease: Fasting blood glucose measurement
0.800 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
Body mass index
CUI: C1305855
Disease: Body mass index
0.800 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
Body mass index procedure
CUI: C0005893
Disease: Body mass index procedure
0.700 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
Finding of body mass index
CUI: C0578022
Disease: Finding of body mass index
0.700 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFLD) is still being examined. 25167786 2015
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Although the influence of a common variant in the glucokinase regulatory gene (GCKR rs780094) in type 2 diabetes mellitus has been well documented, less data however, is available of its role in gestational diabetes mellitus (GDM). 29410004 2018
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. 23456907 2014
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.800 GeneticVariation GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.010 GeneticVariation BEFREE Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study. 20661421 2010
Non-alcoholic Fatty Liver Disease
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
0.790 GeneticVariation BEFREE Because PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants are known to confer susceptibility to NAFLD, we assessed the influence of MBOAT7 rs641738 on hepatic steatosis, and serum levels of CK-18 fragment (a biomarker of hepatocellular injury and apoptosis for NAFLD) after adjusting the effects of PNPLA3, GCKR and TM6SF2 polymorphisms. 29314568 2018
Non-alcoholic Fatty Liver Disease
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
0.790 GeneticVariation BEFREE By studying the genetic variants of obese Taiwanese children, we confirmed that the genetic variants in GCKR rs780094 and PNPLA3 rs738409, but not in NCAN rs2228603, LYPLAL1 rs12137855, and PPP1R3B rs4240624, are associated with an increased risk of NAFLD. 24477042 2014
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.040 GeneticVariation BEFREE Carriers of the C allele of rs780094 were 1.41 (odds ratio, 95% CI, 0.97-2.03) times more likely to develop GDM. 27554451 2017
Non-alcoholic Fatty Liver Disease
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
0.790 GeneticVariation BEFREE Collectively, both our case-control study and meta-analysis confirm a significant association between rs780094 and NAFLD. 30646922 2019
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals. 19241058 2009
Dyslipidemias
CUI: C0242339
Disease: Dyslipidemias
0.030 GeneticVariation BEFREE Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals. 19241058 2009
Body Height
CUI: C0005890
Disease: Body Height
0.700 GeneticVariation GWASCAT Defining the role of common variation in the genomic and biological architecture of adult human height. 25282103 2014
Fasting blood glucose measurement
CUI: C0428568
Disease: Fasting blood glucose measurement
0.800 GeneticVariation GWASCAT Fast and Accurate Genome-Wide Association Test of Multiple Quantitative Traits. 29743933 2018
Glucose tolerance test
CUI: C0017741
Disease: Glucose tolerance test
0.700 GeneticVariation GWASCAT Fast and Accurate Genome-Wide Association Test of Multiple Quantitative Traits. 29743933 2018
Polycystic Ovary Syndrome
CUI: C0032460
Disease: Polycystic Ovary Syndrome
0.010 GeneticVariation BEFREE Furthermore, we provided direct evidence that the copy number, but not the genotype of the CNV in the genomic regions of rs780094(GCKR) is associated with low level of high-density lipoprotein cholesterol in PCOS. 27878529 2017
Malignant neoplasm of colon and/or rectum
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
0.010 GeneticVariation BEFREE Future studies attempting to replicate the association between the GCKR rs780094 variant and the risk of colorectal cancer are warranted. 22354904 2012
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.010 GeneticVariation BEFREE Future studies attempting to replicate the association between the GCKR rs780094 variant and the risk of colorectal cancer are warranted. 22354904 2012