rs780673045, MDM2

N. diseases: 3
Disease: Osteosarcoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Osteosarcoma
CUI: C0029463
Disease: Osteosarcoma
0.020 GeneticVariation BEFREE As a whole, 11 of 29 (38%) analyzed OS presented alterations in some of the analyzed G1 to S-phase checkpoint genes. 15167009 2004
Osteosarcoma
CUI: C0029463
Disease: Osteosarcoma
0.020 GeneticVariation BEFREE The prevalence of these alterations, in conjunction with the reported inactivation of RB in up to 80% of cases, suggests that genetic lesions deregulating the G1 to S cell cycle checkpoint may be an almost constant feature in the pathogenesis of osteosarcoma. 9935200 1999