|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
|
21874001 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs7903146 was genotyped in 1) a population-based sample of 587 twins (55-64 yr) with glucose tolerance ranging from normal to type 2 diabetes and 2) a population of 196 nondiabetic young (22-31 yr) and elderly (57-66 yr) twins.
|
18611970 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) have been shown to be predisposed to type 2 diabetes mellitus across many large studies.
|
21169132 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
A case-control study was performed in Han Chinese subjects with normal control (n=152) and T2DM (n=227), we genotyped rs7903146 and rs11196218 at TCF7L2, rs13266634 at SLC30A8, rs3811951 at PCSK1 and rs2021785 at PCSK2.
|
21437630 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs2476601C/T, rs689A/T, and rs7903146C/T polymorphisms were found to be associated with the risk of LADA, thereby indicating that, genetically, LADA could be an admixture of both T1D and T2D.
|
30456822 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
We report replication of association of four of the six SNPs with T2DM in this Khatri Sikh sample [rs7903146, (p = 0.010); rs11196205, (p = 0.011); rs10885409, (p = 0.002) and rs4918789, (p = 0.029)], under a dominant model conferring odds ratios (ORs) of 1.39, 1.44, 1.57 and 1.36, respectively.
|
18397358 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations were found between type 2 diabetes and rs7903146, rs12255372, rs11196205, rs7901695, rs7895340 and rs4506565, with summary odds ratios (ORs) (95% confidence interval) of 1.39 (1.34-1.45), 1.33 (1.27-1.40), 1.20 (1.14-1.26), 1.32 (1.25-1.39), 1.21 (1.13-1.29) and 1.39 (1.29-1.49), respectively.
|
23188737 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Together, data from our study show that TCF7L2-rs7903146 is associated with PDR in Caucasian T2DM and suggest that TCF7L2 promotes pathological retinal neovascularization via ER stress-dependent upregulation of VEGFA.
|
23434931 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results point to a protein complex binding across rs7903146 within TCF7L2 and suggests a possible mechanism by which this locus confers its T2D risk.
|
24667787 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele.
|
30814579 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The minor allele of each variant was significantly associated with type 2 diabetes; the greatest risk of developing the disease was conferred by rs7903146, with an allelic odds ratio (OR) of 1.31 (95% CI: 1.11 - 1.56, p = 1.96 x 10(-3)).
|
18291022 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjusting for age, gender, drinking, smoking and body mass index (BMI), the association of <i>TCF7L2</i> rs7903146C>T and rs290481 T>C polymorphisms with T2DM was determined.
|
29100364 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903146, a single nucleotide polymorphism found to be associated with type 2 diabetes mellitus in several genomewide association studies, and insulin sensitivity.
|
19573884 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146</span>, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005).
|
31676834 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results indicated that rs7903146C/T polymorphism was significantly associated with T2DM (T vs. C, OR = 1.73, 95% CI = 1.39-2.16).
|
23527206 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The associations between SNPs of TCF7L2 (rs7903146 and rs12255372), SLC16A11 (rs13342232), and ABCA1 (rs9282541) with T2D were analyzed.
|
28101933 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results show that rs7903146 of TCF7L2 gene is an important susceptibility gene for T2D mellitus in the province of Isfahan, Iran.
|
21678030 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs7903146 variant of TCF7L2 significantly increased T2DM risk with an allelic odds ratio of 3.34 (95% CI [1.99-5.60], P < 0.0001).
|
19885641 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D.
|
25839936 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigate the association between gene variant rs7903146 and metabolic parameters and examine in vitro and ex vivo gene expression of <i>TCF7L2</i> in human adipose tissue and progenitor cells from two independent populations of young healthy men with increased risk of type 2 diabetes due to low birth weight (LBW).
|
30721637 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS.
|
29971604 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variants of SNPs rs7903146, rs1552224 and rs11642841 in the control group and rs7903146 in T2DM group showed significant association with both BMI and WC.
|
24435973 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
|
20818381 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The authors then performed a large meta-analysis of 36 studies examining the association of type 2 diabetes mellitus (T2DM) with polymorphisms in the TCF7L2 gene in various ethnicities, containing rs7903146 C-to-T (IVS3C>T), rs7901695 T-to-C (IVS3T>C), a rs12255372 G-to-T (IVS4G>T), and rs11196205 G-to-C (IVS4G>C) polymorphisms and to evaluate the size of gene effect and the possible genetic mode of action.
|
19228405 |
2009 |