Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.060 GeneticVariation BEFREE TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated. 28299838 2017
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.060 GeneticVariation BEFREE In conclusion, the TCF7L2 rs7903146 TT/TC genotype was associated with lower levels of TC, LDL, and HDL in HCV-GT3 patients, and lower levels of HDL-C in HCV-GT1 patients, suggesting a role in cardiovascular disease and a potential use as a biomarker in HIV/HCV-coinfected patients. 25353718 2015
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.060 GeneticVariation BEFREE We described for the first time a strong relationship between the TCF7L2 gene variant rs7903146 and cardiovascular disease in end-stage renal disease patients. 24574000 2014
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.060 GeneticVariation BEFREE We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet. 23942586 2013
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.060 GeneticVariation BEFREE In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease. 19141698 2009
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.060 GeneticVariation BEFREE Our analysis included black and white participants from the Atherosclerosis Risk in Communities study who were free of prevalent CVD at baseline and had been genotyped for rs7903146, rs12255372, rs7901695, rs11196205 and rs7895340 (n=13,369). 18437354 2008