|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
BEFREE |
The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS.
|
29971604 |
2018 |
|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
BEFREE |
Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms.
|
29193419 |
2018 |
|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
BEFREE |
In conclusion, the TCF7L2 rs7903146 polymorphism influences MetS risk, which is augmented by both gender and dietary SFA intake, suggesting novel gene-diet-gender interactions.
|
21543200 |
2012 |
|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
BEFREE |
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS.
|
21749608 |
2011 |
|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
BEFREE |
The two markers located within the TCF7L2 gene showed strong associations with T2D (rs7903146, T allele, odd ratio (OR) = 1.76, p = 0.001 and rs12255372, T allele, OR = 1.78, p = 0.002), but did not show significant association with MS.
|
20503258 |
2010 |
|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
GWASDB |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
BEFREE |
In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease.
|
19141698 |
2009 |
|
Metabolic Syndrome X
|
|
0.870 |
GeneticVariation
|
BEFREE |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004).
|
18853134 |
2008 |