|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In this case-control study of 1,004 breast cancer cases and 1,008 controls, we tested the hypothesis that non-conservative amino acid exchanges in WRN (leu1074Phe), BLM (Met298Thr) and BRCA1 (Pro871Leu) are independently or jointly associated with the risk of breast cancer in Chinese women.
|
19205873 |
2009 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
In this case-control study of 1,004 breast cancer cases and 1,008 controls, we tested the hypothesis that non-conservative amino acid exchanges in WRN (leu1074Phe), BLM (Met298Thr) and BRCA1 (Pro871Leu) are independently or jointly associated with the risk of breast cancer in Chinese women.
|
19205873 |
2009 |
|
Bloom Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this case-control study of 1,004 breast cancer cases and 1,008 controls, we tested the hypothesis that non-conservative amino acid exchanges in WRN (leu1074Phe), BLM (Met298Thr) and BRCA1 (Pro871Leu) are independently or jointly associated with the risk of breast cancer in Chinese women.
|
19205873 |
2009 |
|
Werner Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this case-control study of 1,004 breast cancer cases and 1,008 controls, we tested the hypothesis that non-conservative amino acid exchanges in WRN (leu1074Phe), BLM (Met298Thr) and BRCA1 (Pro871Leu) are independently or jointly associated with the risk of breast cancer in Chinese women.
|
19205873 |
2009 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genotyping of BRCA1 and BRCA2 in the Italian family revealed the presence of two significant polymorphisms: the cancer-associated c.2612C>T SNP in BRCA1, and the c.-26G>A SNP in the BRCA2 gene, acting as an ovarian cancer risk modifier in carriers of deleterious BRCA1 mutations.
|
19287957 |
2009 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genotyping of BRCA1 and BRCA2 in the Italian family revealed the presence of two significant polymorphisms: the cancer-associated c.2612C>T SNP in BRCA1, and the c.-26G>A SNP in the BRCA2 gene, acting as an ovarian cancer risk modifier in carriers of deleterious BRCA1 mutations.
|
19287957 |
2009 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicate that BRCA1 rs799917 polymorphism may contribute to the risk of cervical cancer in this Chinese population, and further validation in other populations are warranted.
|
19482343 |
2009 |
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicate that BRCA1 rs799917 polymorphism may contribute to the risk of cervical cancer in this Chinese population, and further validation in other populations are warranted.
|
19482343 |
2009 |
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicate that BRCA1 rs799917 polymorphism may contribute to the risk of cervical cancer in this Chinese population, and further validation in other populations are warranted.
|
19482343 |
2009 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Joint effect analyses indicated that all the variant genotypes of ZNF350 polymorphisms accounted for increased breast cancer risk among subjects carrying variant homozygote of BRCA1 rs799917, particularly for ZNF350 rs4986773 (OR = 2.03, 95%CI = 1.02-4.05, the test for gene-gene interaction P (int) = 0.059).
|
19484476 |
2009 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Joint effect analyses indicated that all the variant genotypes of ZNF350 polymorphisms accounted for increased breast cancer risk among subjects carrying variant homozygote of BRCA1 rs799917, particularly for ZNF350 rs4986773 (OR = 2.03, 95%CI = 1.02-4.05, the test for gene-gene interaction P (int) = 0.059).
|
19484476 |
2009 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
To assess whether target SNPs are implicated in BC susceptibility, we conducted a case-control population study and observed that germline occurrence of rs799917-BRCA1 and rs334348-TGFR1 significantly varies among populations with different risks of developing BC.
|
20332227 |
2010 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
To assess whether target SNPs are implicated in BC susceptibility, we conducted a case-control population study and observed that germline occurrence of rs799917-BRCA1 and rs334348-TGFR1 significantly varies among populations with different risks of developing BC.
|
20332227 |
2010 |
|
Lymphoma, Non-Hodgkin
|
|
0.020 |
GeneticVariation
|
BEFREE |
Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes.
|
23619945 |
2013 |
|
Malignant transformation
|
|
0.010 |
GeneticVariation
|
BEFREE |
In vivo BRCA1 messenger RNA expression analyses showed that the rs799917 C allele carriers had significantly decreased BRCA1 expression in both normal and cancerous esophagus tissues compared with T allele carriers, suggesting that lower BRCA1 expression may lead to higher risk for malignant transformation of esophagus cells.
|
23749772 |
2013 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that BRCA1 functional rs799917 polymorphism is involved in susceptibility to developing ESCC, alone and in a gene-environment interaction manner.
|
23749772 |
2013 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
In summary, based on the overall results, this meta-analysis strongly suggests that the BRCA1 rs799917 polymorphism is not associated with breast cancer risk.
|
25194442 |
2014 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In summary, based on the overall results, this meta-analysis strongly suggests that the BRCA1 rs799917 polymorphism is not associated with breast cancer risk.
|
25194442 |
2014 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results for the first time indicate that the functional BRCA1 rs799917 polymorphism contributes to g</span>astric cancer susceptibility.
|
25266802 |
2015 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results for the first time indicate that the functional BRCA1 rs799917 polymorphism contributes to g</span>astric cancer susceptibility.
|
25266802 |
2015 |
|
Breast Cancer, Familial
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of four variants was identified within BRCA1 gene (c.442.58 delT, c.2311T>C, c.2612C>T and c.4308T>C) to familial breast cancer across their wild genotypes. miR-1179 was selected as potential miR that targets the region of BRCA1 mRNA containing the c.2311T>C variant within the TT genotype.
|
25273865 |
2014 |
|
Myeloid Leukemia, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, we carried out a case-control study to test the association with CML susceptibility of gene variants located in the miRNA machinery genes AGO1 (rs636832) and GEMIN4 (rs2740348), as well as in the miRNA binding sites of the genes BRCA1 (rs799917) and KRAS (rs61764370).
|
27221928 |
2016 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, despite several limitations, this meta-analysis suggested that BRCA1 P871L genetic variation may be associated with decreased susceptibility to cancer.
|
28427168 |
2017 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, despite several limitations, this meta-analysis suggested that BRCA1 P871L genetic variation may be associated with decreased susceptibility to cancer.
|
28427168 |
2017 |
|
Triple Negative Breast Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations between the rs799917 polymorphism and progression risk were investigated after genotyping 370 TNBC patients.
|
28744749 |
2017 |