|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interaction analysis revealed the CFH SNP rs800292 has a highly significant interaction with the ANGPT2 SNP rs13269021 in nAMD and PCV in the combined analysis.
|
28192798 |
2017 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The variant of I62V could be a promising genetic biomarker of PCV in Asian populations.
|
24520367 |
2014 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
FPR1 rs78488639 interacted with CFH rs800292, HTRA1 rs11200638, and smoking, enhancing risk to exudative AMD and PCV.
|
25277308 |
2014 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant interaction between the CETP SNP rs3764261 and the CFH SNP rs800292 existed in both neovascular AMD and PCV, the rs800292 G allele conferring a significantly increased risk of the diseases only in individuals carrying the risk allele T of rs3764261.
|
24393350 |
2014 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MAF of rs800292 was significantly different between each type of PCV and control (p < 0.0001 and 0.0001 for Type 1 versus control and Type 2 versus control, respectively).
|
23289808 |
2013 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
With meta-analyses, variants in four genes were found to be significantly associated with PCV: LOC387715 rs10490924 (n=9, allelic odds ratio [OR]=2.27, p<0.00001), HTRA1 rs11200638 (n=4, OR=2.72, p<0.00001), CFH rs1061170 (n=4, OR=1.72, p<0.00001), CFH rs800292 (n=5, OR=2.10, p<0.00001), and C2 rs547154 (n=3, OR=0.56, p=0.01).
|
22509112 |
2012 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, an independent association of C2/CFB variants was found for both typical AMD and PCV with age, sex, smoking, and genetic background of ARMS2 A69S and CFH I62V (vs. typical AMD: P = 0.0073, odds ratio [OR] = 0.47; vs. PCV: P = 0.0083, OR = 0.53).
|
22232432 |
2012 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polypoidal CNV group included no subjects homozygous for the A/A genotype of rs800292, whereas 7% of the typical PCV group had this genotype.
|
21896867 |
2011 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotyping of ARMS2 A69S is more informative than that of CFH I62V in understanding the clinical features in patients with PCV.
|
21397333 |
2011 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
CFH Y402H is associated with AMD, tAMD, and PCV, whereas I62V is associated with all three subtypes.
|
20574013 |
2010 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The nonsynonymous variant I62V is a plausible candidate for a causal polymorphism leading to the development of PCV, given its potential for functional consequences on the CFH protein and our own statistical evidence.
|
19187823 |
2009 |
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The SNPs rs3753394 and rs800292 of CFH and rs11200638 of HTRA1 are significantly associated with the risk of PCV in Chinese patients.
|
18515590 |
2008 |