|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In summary, CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.
|
27072204 |
2016 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer.
|
25854352 |
2015 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrated that the two common variations (rs8034191 and rs1051730) at 15q25 are a risk factor associated with increased LC susceptibility, but these associations vary in different ethnic populations.
|
24254305 |
2014 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
There was no overall association between variant rs8034191 and lung cancer risk under the allele frequency model (OR = 1.03, 95 % CI = 0.93-1.13, P heterogeneity = 0.522).
|
25074529 |
2014 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
However, no significant association was found between rs8034191T/C and LC risk.
|
23359026 |
2013 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here, the authors apply a novel method for mediation analysis, allowing for gene-environment interaction, to a lung cancer case-control study (1992-2004) conducted at Massachusetts General Hospital using 2 single nucleotide polymorphisms, rs8034191 and rs1051730, on 15q25.1.
|
22306564 |
2012 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians.
|
22701590 |
2012 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Diplotype analysis of rs3841324 with either rs16969968 or rs8034191 showed that these polymorphisms influenced the lung cancer risk independently.
|
22028403 |
2011 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A>G and rs1051730: G>A, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.
|
21697764 |
2011 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
However, rs7452888 (6q27) was identified as a possible candidate SNP to influence lung cancer survival, while stratified analysis hinted at a possible role for rs8034191</span>, rs16969968 (15q25.1) and rs4324798 (6p22.1) in influencing survival time in lun</span>g cancer patients who were never-smokers, based on a small sample.
|
21750227 |
2011 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We evaluated five of the top candidate SNPs (rs402710, rs2736100, rs4324798, rs16969968, and rs8034191) for their effects on lung cancer risk and overall survival.
|
20056643 |
2010 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Similarly, neither CHRNA3 rs8034191 nor rs1051730 were associated with lung cancer risk.
|
20068085 |
2010 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The goal of this study was to determine whether recently identified genetic variation in 3 SNPs (rs1051730, rs931794, rs8034191) on chromosome 15q25.1 contributes to risk of lung cancer in African Americans.
|
19641473 |
2009 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
GWASDB |
A meta-analysis provided increased support that variation at 15q25.1 (rs8034191; P = 3.24 x 10(-26)), 5p15.33 (rs4975616; P = 2.99 x 10(-9)), and 6p21.33 (rs3117582; P = 4.46 x 10(-10)) influences lung cancer risk.
|
19654303 |
2009 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
A meta-analysis provided increased support that variation at 15q25.1 (rs8034191; P = 3.24 x 10(-26)), 5p15.33 (rs4975616; P = 2.99 x 10(-9)), and 6p21.33 (rs3117582; P = 4.46 x 10(-10)) influences lung cancer risk.
|
19654303 |
2009 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
GWASDB |
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
|
18385738 |
2008 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
GWASDB |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
|
18385676 |
2008 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects.
|
18780872 |
2008 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
GWASDB |
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|
18978787 |
2008 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
GWASDB |
The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects.
|
18780872 |
2008 |