Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
To assess if COPD-associated variants in 15q25.1 are methylation quantitative trait loci, epigenome-wide association analysis of four genetic variants, previously associated with COPD (P < 5 × 10<sup>-8</sup>) in the 15q25.1 locus (rs12914385:C>T-CHRNA3, rs8034191:T>C-HYKK, rs13180:C>T-IREB2 and rs8042238:C>T-IREB2), was performed in the Rotterdam study (n = 1489).
|
29422661 |
2018 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The FPRP test results were as follows: 1) when the prior probability was 0.001 and the OR was 1.5, ADAM33 rs612709, CHRNA3/5 rs1051730, CHRNA3/5 rs8034191, CHRNA3/5 rs16969968, and TGFB1 rs1800470 were truly associated with COPD risk (FPRP < 0.2); 2) when the prior probability was 0.000001 and the OR was 1.5, all the variants except TGFB1 rs1800470 remained noteworthy; and 3) when the probability was 0.000001 and the OR was 1.2, ADAM33 rs612709 and CHRNA3/5 rs1051730 remained true positives.
|
27323020 |
2016 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Significant associations between the 4 SNPs and COPD were identified under allele (rs1051730: OR = 1.14, 95%CI = 1.10-1.18; rs8034191: OR = 1.29, 95%CI = 1.18-1.41; rs6495309: OR = 1.26, 95%CI = 1.09-1.45; rs16969968: OR = 1.27, 95%CI = 1.17-1.39) and genotype models.
|
25051068 |
2014 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Our analysis revealed that effects of two linked variants (rs1051730 and rs8034191) in the AGPHD1/CHRNA3 cluster on COPD development are significantly, yet not entirely, mediated by the smoking-related phenotypes.
|
23299987 |
2013 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
In the LEUVEN cohort, rs1051730 AA-carriers and rs8034191 GG-carriers had a two-fold increased risk to suffer from COPD GOLD IV (OR 2.29, 95% confidence interval [CI] = 1.11-4.75; p = 0.025 and OR = 2.42, 95% [CI] = 1.18-4.95; p = 0.016, respectively).
|
23349703 |
2013 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The SNP rs8034191 near CHRNA3/5 locus was significantly associated with pack-years of smoking in COPD patients (P=0.033).
|
22914670 |
2012 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).
|
22461431 |
2012 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
GWASDB |
Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.
|
21921092 |
2011 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
The C allele of the rs8034191 SNP was estimated to have a population attributable risk for COPD of 12.2%.
|
19300482 |
2009 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The C allele of the rs8034191 SNP was estimated to have a population attributable risk for COPD of 12.2%.
|
19300482 |
2009 |
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
GWASDB |
The C allele of the rs8034191 SNP was estimated to have a population attributable risk for COPD of 12.2%.
|
19300482 |
2009 |
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent.
|
27072204 |
2016 |
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In summary, CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.
|
27072204 |
2016 |
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer.
|
25854352 |
2015 |
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer.
|
25854352 |
2015 |
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrated that the two common variations (rs8034191 and rs1051730) at 15q25 are a risk factor associated with increased LC susceptibility, but these associations vary in different ethnic populations.
|
24254305 |
2014 |
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrated that the two common variations (rs8034191 and rs1051730) at 15q25 are a risk factor associated with increased LC susceptibility, but these associations vary in different ethnic populations.
|
24254305 |
2014 |
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
There was no overall association between variant rs8034191 and lung cancer risk under the allele frequency model (OR = 1.03, 95 % CI = 0.93-1.13, P heterogeneity = 0.522).
|
25074529 |
2014 |
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
There was no overall association between variant rs8034191 and lung cancer risk under the allele frequency model (OR = 1.03, 95 % CI = 0.93-1.13, P heterogeneity = 0.522).
|
25074529 |
2014 |
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
However, no significant association was found between rs8034191T/C and LC risk.
|
23359026 |
2013 |
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
However, no significant association was found between rs8034191T/C and LC risk.
|
23359026 |
2013 |
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here, the authors apply a novel method for mediation analysis, allowing for gene-environment interaction, to a lung cancer case-control study (1992-2004) conducted at Massachusetts General Hospital using 2 single nucleotide polymorphisms, rs8034191 and rs1051730, on 15q25.1.
|
22306564 |
2012 |