|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
An unweighted genetic risk score (GRS) was calculated for two <i>FTO</i> single-nucleotide polymorphisms (rs8050136 and rs2388405) by summation of the number of risk alleles for obesity.
|
31516636 |
2019 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a case-control study with 829 participants, factors involved with metabolism and obesity were assessed, including biochemical lipid and liver markers, and the fat mass and obesity-associated (FTO) single nucleotide polymorphism (SNP) rs8050136.
|
27905213 |
2017 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In single locus analysis, FTO rs8050136 CA (p = 0.0001; OR (95% CI) = 2.4 (1.7-3.4) and AA (p = 0.0001; OR (95% CI) = 3.1 (1.9-5.2); FTO rs1421085 TA (p = 0.0001; OR (95% CI) = 2.1 (1.4-3.0) and AA (p = 0.0001; OR (95% CI) = 3.0 (1.8-5.0); FTO rs9939609 TC (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and CC (p = 0.0001; OR (95% CI) = 4.2 (2.5-7.3) along with TG (p = 0.001; OR (95% CI) = 2.1 (1.3-3.2) and GG (p = 0.021; OR (95% CI) = 3.8 (1.2-11.8) genotypes of FTO rs17817449 with GT (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and TT (p = 0.012; OR (95% CI) = 3.3 (1.8-3.6) genotypes of IRX3 rs3751723 were significantly associated with obesity.
|
26440677 |
2016 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
A region in the first intron of the fat mass- and obesity-associated (FTO) gene, encompassing markers rs9939973, rs8050136, and rs9939609, has been consistently associated with obesity and body mass index (BMI) in different populations.
|
26529281 |
2015 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here we examined association of FTO variants (rs9939609 and rs8050136) with obesity and related anthropometric and biochemical traits in 3,126 Indian children (aged 11-17 years) including 2,230 normal-weight and 896 over-weight/obese children.
|
23091647 |
2012 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations were detected between obesity risk and the five polymorphisms: rs9939609 (OR: 1.31, 95% CI: 1.26 to 1.36), rs1421085 (OR: 1.43, 95% CI: 1.33 to 1.53), rs8050136 (OR: 1.25, 95% CI: 1.13 to 1.38), rs17817449 (OR: 1.54, 95% CI: 1.41 to 1.68), and rs1121980 (OR: 1.34, 95% CI: 1.10 to 1.62).
|
21651756 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both FTO rs8050136 (P(age, sex-adjusted)=0.019; odds ratio (OR) (95% confidence intervals (CI)): 1.35 (1.05, 1.73)) and GNPDA2 rs10938397 (P(age, sex-adjusted)=3 × 10(-3); OR (95% CI): 1.34 (1.11, 1.63)) were significantly associated with persistent central obesity.
|
21147891 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
|
21706003 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
|
21935397 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
among South Indians, the rs9940128 A/G, rs11076023 A/T, and rs1588413 C/T variants of the FTO gene were associated with T2DM, whereas the rs8050136 C/A variant was associated with obesity.
|
21175269 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population.
|
21814223 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings indicate that the two variants (rs9939609 and rs8050136) in the FTO gene contribute to obesity and T2D in the Asian populations.
|
20057365 |
2010 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variant rs8050136 lies within intron 1 of the FTO gene on chromosome 16 and marks a locus strongly associated with type 2 diabetes and obesity and widely replicated across many populations.
|
20009087 |
2010 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.
|
18159244 |
2007 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
FTO rs8050136 being associated with type 2 diabetes through its effect on obesity); differential linkage disequilibrium across studies of the identified genetic markers with the respective culprit polymorphisms (e.g., possibly the case for CDKAL1 polymorphisms or for rs9300039 and markers in linkage disequilibrium, as shown by additional studies); and potential bias.
|
17786212 |
2007 |