|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity.
|
20661738 |
2011 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
An association between disease status and the sIL-6R rs8192284 (A358D) variant was tested in 965 patients with RA and 988 unrelated healthy controls.
|
19713205 |
2010 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity.
|
20551110 |
2010 |
|
Fibrinogen assay
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.
|
28107422 |
2017 |
|
Fibrinogen assay
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
|
20031577 |
2009 |
|
C-reactive protein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|
18439548 |
2008 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that rs12083537 and rs8192284 in the IL6R gene might be related to the risk of IS in MetS patients.
|
31836512 |
2020 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
The characteristics of the MetS components associated with different alleles and genotypes of the IL-6R rs8192284 SNP were compared.
|
23094986 |
2012 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
In an exploratory analysis, rs8192284 showed significant interactions with CRP levels in relation to diabetes risk (P for interaction = 0.026).
|
18852330 |
2009 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
In an exploratory analysis, rs8192284 showed significant interactions with CRP levels in relation to diabetes risk (P for interaction = 0.026).
|
18852330 |
2009 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
IL6R genetic variations, especially SNP7 (rs8192284, Asp358Ala), were significantly associated with plasma IL-6 levels but not with diabetes risk in women.
|
17898129 |
2007 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
IL6R genetic variations, especially SNP7 (rs8192284, Asp358Ala), were significantly associated with plasma IL-6 levels but not with diabetes risk in women.
|
17898129 |
2007 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that rs12083537 and rs8192284 in the IL6R gene might be related to the risk of IS in MetS patients.
|
31836512 |
2020 |
|
Dengue Fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found IL4R-rs1805016 GG genotype and G-allele carriers and IL6R-rs8192284 AA genotype associated with clinical dengue in the pooled and Huila samples.
|
30228077 |
2019 |
|
Multiple Myeloma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Unlike the IL-6 promoter rs1800795 (G>C) polymorphism, the IL-6R rs8192284 (A>C) polymorphism may be associated with MM risk.
|
27525545 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The prognostic role of the functional IL-6 (promoter) rs1800795 and the IL-6R (receptor) rs8192284 single nucleotide polymorphisms (SNP) was studied in patients with advanced gastric cancer treated with palliative chemotherapy.
|
24886605 |
2014 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The prognostic role of the functional IL-6 (promoter) rs1800795 and the IL-6R (receptor) rs8192284 single nucleotide polymorphisms (SNP) was studied in patients with advanced gastric cancer treated with palliative chemotherapy.
|
24886605 |
2014 |
|
Hematologic Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL-6 receptor rs8192284 was associated with an increased risk of hematologic malignancy (combined ORG 1.42, 95%CI 1.03-1.96), including multiple myeloma (ORG 1.39, 95%CI 0.99-1.95).
|
24059848 |
2013 |
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data showed no influence of the selected variants in global SSc susceptibility (rs8192284: P=0.67, odds ratios (OR)=0.98; rs2228044: P=0.99, OR=1.00).
|
22742541 |
2012 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to investigate whether the functional genetic variants rs8192284 and rs2228044 previously associated with several autoimmune diseases, located within the IL-6 receptor (IL-6R) subunits IL6R and IL6ST genes, respectively, are involved in the susceptibility to SSc and/or its major clinical subphenotypes.
|
22742541 |
2012 |
|
Sjogren's Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is suggested that rs1143634 of IL1B and rs8192284 of IL6R act as susceptibility variations in Korean non-Sjogren dry eye patients.
|
22128229 |
2011 |
|
Delirium
|
|
0.010 |
GeneticVariation
|
BEFREE |
Rs1800697 and rs1800797 in the IL6 gene, rs8192284 in the IL6R gene, and rs4073 in the IL8 gene were not associated with the development of delirium.
|
21851175 |
2011 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL-6R rs8192284 A/C and rs2229238 C/T variants are associated with dyslipidemia in girls, but not in boys.
|
21835044 |
2011 |
|
Trichohepatoenteric Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the role of the IL-6 (rs1524107-C/T) and IL-6 receptor (IL-6R, rs8192284-A/C, Asp358Ala) SNPs in modulating IL-6 levels and the syndrome.
|
20186139 |
2010 |