|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped seven tagging SNPs in these genes (rs1805794, rs709816; rs1063054; rs7141928, rs1799794, rs861530, rs861539) with the aim to analyse their association with acute lymphoblastic leukaemia (ALL), a disease, that is characterised by elevated genetic instability.
|
25176580 |
2014 |
|
Adenoma of large intestine
|
|
0.020 |
GeneticVariation
|
BEFREE |
We used a case-control study design (157 carcinomas, 983 adenomas and 399 controls) to test the association between five polymorphisms in these DNA repair genes (XRCC1 Arg194Trp, Arg280His, Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln), and risk of colorectal adenomas and carcinomas in a Norwegian cohort.
|
16542436 |
2006 |
|
Adenoma of large intestine
|
|
0.020 |
GeneticVariation
|
BEFREE |
Using a large sigmoidoscopy-based case-control study (753 cases and 799 controls) in Los Angeles County, we investigated possible associations between single-nucleotide polymorphisms in the XRCC1 (codons 194 Arg/Trp and codon 399 Arg/Gln) and XRCC3 (codon 241 Thr/Met) genes and colorectal adenoma risk and their possible role as modifiers of the effect of monounsaturated fatty acid, the ratio of omega-6/omega-3 polyunsaturated fatty acids, and antioxidant intake.
|
15767338 |
2005 |
|
Adult Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ(2) = 6.558; p = 0.0053).
|
26511493 |
2016 |
|
Adult Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genotypic and allelic frequencies of seven common polymorphisms in DNA repair genes involved in nucleotide excision repair (ERCC1 rs11615, ERCC2 rs13181, ERCC6 rs4253079), base excision repair (APEX1 rs1130409, XRCC1 rs25487), double-strand break repair (XRCC3 rs861539) and mismatch repair (MLH1 rs1800734) pathways were analyzed in 115 glioblastoma patients and 200 healthy controls.
|
24325908 |
2014 |
|
Adult Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined XRCC3 Thr241Met polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma samples.
|
22370935 |
2012 |
|
Astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We suggest that XRCC3 Thr241Met polymorphism is involved in susceptibility for developing astrocytomas and glioblastomas.
|
22370935 |
2012 |
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
We undertook a case-control study of 212 urothelial bladder cancer (UBC) cases and 250 controls to investigate the association between OGG1 (C1245G rs1052133), XRCC3 (C18067T, rs861539) and XRCC7 (G6721T, rs7003908) polymorphisms and bladder cancer susceptibility by PCR-RFLP and the ARMS method.
|
19815090 |
2010 |
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Taken together, our meta-analysis had suggested an increased risk role of XRCC3 241MM genotype in bladder cancer among all subjects, and the effect of T241M polymorphism on bladder susceptibility should be studied with a larger, stratified population.
|
20947146 |
2011 |
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests the participation of XRCC3 T241M in the susceptibility for bladder cancer and breast cancer, especially in Caucasians, and XRCC3 T241M polymorphism is associated with decreased lung cancer risk.
|
23562721 |
2013 |
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
In summary, our meta-analysis indicates that XRCC3 Thr241Met polymorphism may be weakly associated with the risk of bladder cancer.(Cancer Sci 2010).
|
20500515 |
2010 |
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
The combined results based on all studies suggested that XRCC3 Thr241Met was associated with blad</span>der cancer risk under homozygote and recessive models.
|
24085356 |
2014 |
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Gene-environment interaction with arsenic exposure was observed in relation to bladder cancer risk for a variant allele of the double-strand break repair gene XRCC3 T241M (adjusted OR 2.8 (1.1-7.3)) comparing to homozygous wild type among those in the top arsenic exposure decile (interaction p-value 0.01).
|
19429237 |
2009 |
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
DNA repair gene XRCC3 T241M polymorphism and bladder cancer risk in a Chinese population.
|
22299591 |
2012 |
|
Brain Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We evaluated the association of SNPs Arg194Trp, Arg280His, and Arg399Gln in the X-ray cross-complementing group 1 (XRCC1) and Thr241Met in the X-ray cross-complementing group 3 (XRCC3) DNA repair genes with the risk of brain tumors.
|
18330515 |
2008 |
|
Brain Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subgroup analysis by race suggested that the XRCC3 Thr241Met polymorphism was associated with increased risk of brain tumors in Asians under all four contrast models (Met vs. Thr: OR = 1.22, 95 % CI 1.09-1.36, P < 0.01; MetMet vs. ThrThr: OR = 1.89, 95 % CI 1.38-2.57, P < 0.01; MetMet vs. ThrThr/ThrMet: OR = 1.78, 95 % CI 1.31-2.40, P < 0.01; and MetMet vs. ThrThr/ThrMet: OR = 1.19, 95 % CI 1.04-1.36, P = 0.01).
|
24061639 |
2014 |
|
Breast Cancer, Familial
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest XRCC1 Arg399Gln and XRCC3 Thr241Met DNA repair polymorphisms as important biomarkers to sporadic breast cancer susceptibility, as well as, RAD51 G135C polymorphism as a real risk modifier in familial breast cancer cases.
|
17063276 |
2007 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The XRCC3-5'UTR (rs1799794) G allele frequency was higher in cancer patients while XRCC1 (rs25487) and XRCC3 (rs861539) did not show any significant correlation with susceptibility of BC in the selected Jordanian population.
|
26446325 |
2015 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR=1.21, 95% CI: 0.78-1.88); Arg399Gln (OR=1.20, 95% CI: 0.80-1.79); XRCC3: Thr241Met (OR=1.04, 95% CI: 0.76-1.41).
|
16963196 |
2006 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms XRCC1-R399Q and XRCC3-T241M and the risk of breast cancer at the Ontario site of the Breast Cancer Family Registry.
|
15066923 |
2004 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the Thr241Met genotype of the XRCC3 polymorphism slightly increased the risk of local metastasis in breast cancer patients (OR 2.56, 95% CI 1.27-5.17).
|
19426727 |
2009 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests the participation of XRCC3 T241M in the susceptibility for bladder cancer and breast cancer, especially in Caucasians, and XRCC3 T241M polymorphism is associated with decreased lung cancer risk.
|
23562721 |
2013 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping was conducted for polymorphisms in four genes involved in repair of radiation-induced DNA damage, the double-strand break repair pathway: X-ray cross-complementing group 3 (XRCC3) codon 241 Thr/Met, Nijmegen breakage syndrome 1 (NBS1) codon 185 Glu/Gln, X-ray cross-complementing group 2 (XRCC2) codon 188 Arg/His, and breast cancer susceptibility gene 2 (BRCH2) codon 372 Asn/His.
|
16214912 |
2005 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We can conclude that XRCC3 Thr241Met polymorphism might be associated with breast cancer risk, especially in Asian populations and in patients without family history of breast cancer.
|
26498491 |
2015 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
XRCC3 codon 241 Thr/Met or Met/Met genotype moderately increased the risk of breast cancer (OR = 1.4, 95% CI: 0.87-2.33), but not significant in this study.
|
17063279 |
2007 |