|
Secondary Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
XRCC3 Thr241Met gene polymorphism was associated with osteosarcoma risk, but XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis.
|
30539867 |
2018 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The C allele of rs861539 and T allele of rs1799782 Interaction between rs1799782 and obesity and haplotype T- C were all associated with increased PTC risk.
|
30165355 |
2018 |
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The XRCC3 241Thr/Met genotype was more frequent in the LVH (+) group than in the LVH (-) group (42.3 vs. 13.7%, χ2 = 7.85, p = 0.0051).
|
29626209 |
2018 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that <i>XRCC3</i> genotypes with polymorphisms at rs861539 may play a role in determining individual susceptibility to childhood ALL in this Taiwanese population.
|
30532590 |
2018 |
|
Sleep Apnea, Obstructive
|
|
0.010 |
GeneticVariation
|
BEFREE |
The XRCC3 rs861539 polymorphism conferred susceptibility to OSA in
|
28345844 |
2017 |
|
Ovarian Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The obtained results indicate that XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women.
|
26801223 |
2016 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding the XRCC3 Thr241Met polymorphism, an association with CCRCC was found only in XRCC3 Thr241Met/XPD Lys751Gln combined genotypes.
|
26682510 |
2016 |
|
Primary differentiated carcinoma of thyroid gland
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of XRCC1 (rs25487, rs1799782) and XRCC3 (rs861539), may play a critical role in DTC development and progression.
|
26938431 |
2016 |
|
Fibroid Tumor
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T allele (CT and TT genotypes) of XRCC3 rs861539 contributes to increased risk of leiomyoma among Taiwanese women and may serve as a early detection and predictive marker.
|
26254358 |
2015 |
|
Uterine Fibroids
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T allele (CT and TT genotypes) of XRCC3 rs861539 contributes to increased risk of leiomyoma among Taiwanese women and may serve as a early detection and predictive marker.
|
26254358 |
2015 |
|
Carcinoma, Transitional Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine the association between polymorphisms of the DNA repair genes, XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln, with urinary arsenic profiles and UC.
|
25018058 |
2014 |
|
Skin carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the current study, we aim to assess the impact of XRCC1 R399Q and XRCC3 T241M polymorphisms on the risk of NMSC associated with sunlight and arsenic exposure.
|
25218703 |
2014 |
|
Lymphoma, Follicular
|
|
0.010 |
GeneticVariation
|
BEFREE |
The following genotypes in combination with hair dye use before 1980 were associated with FL risk: BRCA2 rs144848 AC+CC [odds ratio (OR) (95% confidence interval (CI)) 3.28(1.27-8.50)], WRN rs1346044 TT [OR(95% CI) 2.70(1.30-5.65)], XRCC3 rs861539 CT+TT [OR(95% CI) 2.76(1.32-5.77)], XRCC4 rs1805377 GG [OR(95% CI) 2.07(1.10-3.90)] and rs1056503 TT [OR(95% CI) 2.17(1.16-4.07)], ERCC1 rs3212961 CC [OR(95% CI) 1.93(1.00-3.72)], RAD23B rs1805329 CC [OR(95% CI) 2.28(1.12-4.64)], and MGMT rs12917 CC, rs2308321 AA, and rs2308327 AA genotypes [OR(95% CI) 1.96(1.06-3.63), 2.02(1.09-3.75), and 2.23(1.16-4.29), respectively].
|
25178586 |
2014 |
|
Urothelial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine the association between polymorphisms of the DNA repair genes, XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln, with urinary arsenic profiles and UC.
|
25018058 |
2014 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the T allele of XRCC3 rs861539, which has an interaction with areca chewing habit in oral carcinogenesis, may be an early marker for oral cancer in Taiwanese.
|
24922659 |
2014 |
|
Experimental Organism Basal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results indicate an increased risk of squamous cell carcinoma (SCC) for the homozygous variant genotype of XRCC1 R399Q (OR 2.53, 95% CI 1.14-5.65) and a protective effect against basal cell carcinoma (BCC) for the homozygous variant genotype of XRCC3 T241M (OR 0.61, 95% CI 0.41-0.92), compared with the respective homozygous common genotypes.
|
25218703 |
2014 |
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped seven tagging SNPs in these genes (rs1805794, rs709816; rs1063054; rs7141928, rs1799794, rs861530, rs861539) with the aim to analyse their association with acute lymphoblastic leukaemia (ALL), a disease, that is characterised by elevated genetic instability.
|
25176580 |
2014 |
|
Meningioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.
|
23534771 |
2013 |
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
COPD patients with the risk allele XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) showed higher DNA damage by comet assay.
|
24053728 |
2013 |
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, when stratifying by the status of smoking and hepatitis B virus infection, the XRCC3 Thr241Met variant was significantly associated with HCC risk among the HBsAg (+) individuals but not the HBsAg (-) individuals, smokers, and non-smokers.
|
23824570 |
2013 |
|
Childhood Astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined XRCC3 Thr241Met polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma samples.
|
22370935 |
2012 |
|
Astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We suggest that XRCC3 Thr241Met polymorphism is involved in susceptibility for developing astrocytomas and glioblastomas.
|
22370935 |
2012 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the light of these findings, we investigated whether DNA repair gene polymorphisms (XRCC1 Arg399Gln, XRCC3 Thr241Met XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys) account for an increased risk of Parkinson's disease (PD).
|
22224629 |
2012 |
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
The subject of investigation in the reported study was the distribution of genotypes and the prevalence of alleles of the RAD51 G135C, XRCC2 Arg188His and XRCC3 Thr241Met polymorphism in 230 cases of sporadic endometrial cancer; the polymorphisms were determined by polymerase chain reaction-restriction fragment-length polymorphism methods.
|
22487057 |
2012 |
|
Oral Submucous Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gene-gene interaction analysis by multifactor dimensionality reduction (MDR) revealed that XRCC3 Thr 241 Met had the largest univariate effect followed by XRCC3 Thr 241 Met - NAT2 A857G in men that presents a highly synergistic interaction as one of the potential combinations of single nucleotide polymorphisms (SNPs) to increase the risk of OSF in men if exposed to arecanut or smokeless tobacco usage.
|
22092501 |
2012 |