rs861539, KLC1;XRCC3

N. diseases: 104
Disease: Carcinoma, Basal Cell ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Carcinoma, Basal Cell
CUI: C4721806
Disease: Carcinoma, Basal Cell
0.020 GeneticVariation BEFREE The results indicate an increased risk of squamous cell carcinoma (SCC) for the homozygous variant genotype of XRCC1 R399Q (OR 2.53, 95% CI 1.14-5.65) and a protective effect against basal cell carcinoma (BCC) for the homozygous variant genotype of XRCC3 T241M (OR 0.61, 95% CI 0.41-0.92), compared with the respective homozygous common genotypes. 25218703 2014
Carcinoma, Basal Cell
CUI: C4721806
Disease: Carcinoma, Basal Cell
0.020 GeneticVariation BEFREE The data from this study show overall risk modulation of BCC by variant allele for T241M polymorphism in XRCC3 and gender-specific effect by E185Q polymorphism in NBS1. 16501254 2006