rs863225281, ALK

N. diseases: 12
Disease: hereditary neuroblastoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
hereditary neuroblastoma
CUI: C3899155
Disease: hereditary neuroblastoma
0.010 GeneticVariation BEFREE In this study, we show that the novel ALK inhibitor alectinib effectively suppressed cell proliferation and induces apoptosis in NB cell lines with either wild-type ALK or mutated ALK (F1174L and D1091N) by blocking ALK-mediated PI3K/Akt/mTOR signaling. 28455243 2017