|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No publication bias was found for all the meta-analysis as suggested by the Begg funnel plot and Egger tests.These results suggested that variants MDM2 SNP309 and p53 Arg72Pro are susceptibility factors for HCC; however, more studies are warranted to validate the results.
|
28885338 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that Arg72Pro polymorphism in a WT p53 context may act as a primary driver of epigenetic changes in HCC.
|
25889455 |
2015 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, our findings further suggest that the combination of MDM2 SNP 309 and TP53 Arg72Pro genotypes confers higher risk to develop HCC.
|
24376578 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of hepatocellular carcinoma (HCC) remains inconsistent.
|
23292895 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In subgroup analysis by ethnicity, the pooled results suggested that the p53 codon 72 Arg/Pro polymorphism was associated with an increased risk of HCC in Asians and Caucasians (for Asians, ORProPro vs. ArgArg + ArgPro=1.17 (95 % CI, 1.02-1.34), P OR=0.025; for Caucasians, ORProPro vs. ArgArg = 1.65 (95 % CI, 1.07-2.56), P OR=0.025; ORProPro vs. ArgArg + ArgPro=1.74 (95 % CI, 1.14-2.66), P OR=0.010).
|
23564481 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02).
|
21607615 |
2012 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analyses of available data suggest an obvious association between the TP53 Arg72Pro and HCC risk in Caucasians.
|
23167333 |
2012 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we did not find any main effect of TP53 Arg72Pro on HCC risk in this population.
|
20309940 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results indicated that Arg72Pro is associated with higher susceptibility to cancer in some tumor sites, mainly hepatocarcinoma.
|
20886596 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patients with chronic HBV infection.
|
18390844 |
2008 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population.
|
15633234 |
2005 |