|
ovarian neoplasm
|
|
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
No point mutation but a codon 31ser-->arg polymorphism of the WAF-1/CIP-1/p21 tumor suppressor gene in nasopharyngeal carcinoma (NPC): the polymorphism distinguishes Caucasians from Chinese.
|
7606201 |
1995 |
|
Nasopharyngeal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
No point mutation but a codon 31ser-->arg polymorphism of the WAF-1/CIP-1/p21 tumor suppressor gene in nasopharyngeal carcinoma (NPC): the polymorphism distinguishes Caucasians from Chinese.
|
7606201 |
1995 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, paired normal tissue was available for 3 of 20 breast carcinomas with the Ser31Arg transversion.
|
9006333 |
1997 |
|
Childhood Non-Hodgkin Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese.
|
15291355 |
2004 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese.
|
15291355 |
2004 |
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association between endometrial cancer and the polymorphism at codon 31 (AGC/serine to AGA/arginine [Ser(31)Arg]) of the p21 gene, which is known to be a downstream mediator of p53, has also been reported.
|
15099969 |
2004 |
|
Adult Non-Hodgkin Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese.
|
15291355 |
2004 |
|
Lymphoma, Non-Hodgkin, Familial
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese.
|
15291355 |
2004 |
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association between endometrial cancer and the polymorphism at codon 31 (AGC/serine to AGA/arginine [Ser(31)Arg]) of the p21 gene, which is known to be a downstream mediator of p53, has also been reported.
|
15099969 |
2004 |
|
Skin toxicity
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore assessed the association between TP53 Arg72Pro, p53PIN3 and p21 Ser31Arg polymorphisms and the risk of acute skin toxicity after radiotherapy in a prospective study of 446 female breast cancer patients (average age 60.3+/-9.0 years) receiving radiotherapy after breast conserving surgery.
|
16331344 |
2006 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pro) and p21/CDKN1A (Ser31Arg) and smoking on lung cancer risk.
|
17059853 |
2007 |
|
Renal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped three single nucleotide polymorphisms of three genes (p53 Arg(72)Pro, p21 Ser(31)Arg, and MDM2 SNP309) in 200 patients with renal cancer and 200 age- and gender-matched healthy subjects.
|
17634539 |
2007 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC.
|
17634539 |
2007 |
|
Squamous cell carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
|
17059853 |
2007 |
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results for the p21 Ser31Arg polymorphism suggested that 31Ser is a moderate-risk allele for squamous-cell carcinoma.
|
17059853 |
2007 |
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC.
|
17634539 |
2007 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pro) and p21/CDKN1A (Ser31Arg) and smoking on lung cancer risk.
|
17059853 |
2007 |
|
Malignant neoplasm of kidney
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped three single nucleotide polymorphisms of three genes (p53 Arg(72)Pro, p21 Ser(31)Arg, and MDM2 SNP309) in 200 patients with renal cancer and 200 age- and gender-matched healthy subjects.
|
17634539 |
2007 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pro) and p21/CDKN1A (Ser31Arg) and smoking on lung cancer risk.
|
17059853 |
2007 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
550 samples (275 cases/275 control) of peripheral blood obtained from women (aged 22-87 years) with breast cancer and from healthy women (aged 23-87 years) were genotyped for frequencies of the following gene variances: R72P/rs1042522 (gene TP53) and S31R/ss4388499 (gene p21).
|
20127253 |
2010 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
550 samples (275 cases/275 control) of peripheral blood obtained from women (aged 22-87 years) with breast cancer and from healthy women (aged 23-87 years) were genotyped for frequencies of the following gene variances: R72P/rs1042522 (gene TP53) and S31R/ss4388499 (gene p21).
|
20127253 |
2010 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
GeneticVariation
|
BEFREE |
We suggest that SNPs in the P53 pathway, especially the P21 ser31arg polymorphism and combined polymorphisms especially the P21/ MDM2 might be genetic susceptibility factors in the pathogenesis of AML.
|
23167335 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Gastric Adenocarcinoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |