|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer.
|
22719192 |
2012 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study found significant association between rs895819 polymorphism in pre-miR-27a and CRC risk.
|
25078482 |
2014 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Through genotyping the rs895819 SNP in 254 colorectal cancer (CRC) patients and 238 healthy controls by polymerase chain reaction-restricted fragment length polymorphism, a case-control study was performed to investigate a possible association between a common A/G polymorphism (rs895819) within hsa-mir-27a and susceptibility to CRC in a Chinese Han population.
|
25222241 |
2014 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, polymorphisms of miR-149 (rs2292832; CT vs TT: odds ratio [OR] = 0.816, 95% confidence interval [CI] = 0.691-0.963; CC+CT vs TT: OR = 0.834, 95%CI = 0.715-0.972) and pre-miR-27a (rs895819; GG vs AA: OR = 1.534, 95%CI = 1.148-2.049; GG+AG vs AA: OR = 1.324, 95%CI = 1.066-1.645) were found to be associated with CRC in our analysis.
|
27706637 |
2016 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations.
|
27751356 |
2016 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicated that miR-27a might be involved in the development and progression of CRC, genotype GG within rs895819 might be a genetic susceptible factor for CRC.
|
26302683 |
2016 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To summarize, our results indicated that rs895819 was a protective factor for cancer in Caucasians and could increase colorectal cancer risk but decrease breast cancer risk.
|
28415619 |
2017 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, rs895819 was associated with increased risk of colorectal cancer (GG <i>vs.</i> AA: OR = 1.56, 95% CI = 1.31-1.85; GG <i>vs.</i> AA/AG: OR = 1.53, 95% CI = 1.30-1.79; G <i>vs.</i> A: OR = 1.19, 95% CI = 1.09-1.30) and lung cancer (GG <i>vs.</i> AA/AG: OR = 1.43, 95% CI = 1.00-2.04).
|
29088869 |
2017 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the other hand, rs895819 (miR-27a) GG carriers were more susceptible to CRC (OR = 1.47, 95% CI = 1.21-1.78, P = <0.05) in a recessive genetic model.
|
30447914 |
2018 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggested that rs895819 polymorphism was correlated with increased risk of colorectal cancer and breast cancer, but not all types of cancer.
|
31838252 |
2020 |