|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Pre-miR-27a rs895819 polymorphism and risk of diffuse large B-cell lymphoma.
|
31797450 |
2020 |
|
Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, these findings indicate that rs895819 A > G might reduce the expression of mature miR-27a, and leading a higher level of TGFBR1, ultimately inhibiting the development of DLBCL.
|
31797450 |
2020 |
|
Malaria, Cerebral
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the relationship of microRNA SNP to cerebral malaria outcome, we performed TaqMan Genotyping Assays in 110 cerebral malaria and 207 uncomplicated malaria cases for three candidate microRNA SNPs (rs895819 of microRNA-27a, rs57095329 and rs2910164 of microRNA-146a).
|
30599464 |
2019 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Limited or conflicting evidences were found for the associations of the other variants (rs11134527, rs139365823, rs76987351, rs3746444, rs4938723, rs2292832, rs41291957, rs895819) and risk of CHD.
|
31702616 |
2019 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the pre-miR-27a rs895819 polymorphism is associated with MI susceptibility in the Chinese Han population, which probably due to influence the HDL-C levels.
|
29304813 |
2018 |
|
Esophageal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, no association was found between rs895819 and risk of gastric cancer or esophageal cancer.
|
29088869 |
2017 |
|
Gastritis, Atrophic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, miR-27a rs895819 is implicated as a biomarker for gastric cancer and atrophic gastritis risk, and interacts with H. pylori in gastric carcinogenesis.
|
28150722 |
2017 |
|
Malignant neoplasm of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, no association was found between rs895819 and risk of gastric cancer or esophageal cancer.
|
29088869 |
2017 |
|
Esophageal Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, no association was found between rs895819 and risk of gastric cancer or esophageal cancer.
|
29088869 |
2017 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
|
0.010 |
GeneticVariation
|
BEFREE |
MiR-27a rs895819 is involved in increased atrophic gastritis risk, improved gastric cancer prognosis and negative interaction with Helicobacter pylori.
|
28150722 |
2017 |
|
Atrial Septal Defects
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPs of miR-27a (rs895819, T>C) and miR-499 (rs3746444, A>G) showed diverse association with ASD, VSD, or PDA, but the differences were not statistically significant.
|
27813602 |
2016 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
microRNA-27a rs895819 is associated with obesity in HIV infected preeclamptic Black South African women on HAART.
|
27919232 |
2016 |
|
HIV Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of this study suggests that miR-27a rs895819 may not be associated with PE susceptibility; however, the miR-27a TC/CC genotype increases susceptibility to elevated BMI in PE, which may be significantly influenced by co-morbid HIV infection among pregnant women on HAART.
|
27919232 |
2016 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor allele C of rs895819 was found to be associated with the increased risk of developing PCa under dominant (P=0.035; OR=1.38, 95%CI 1.02-1.86) and overdominant (P=0.04; OR=1.37, 95%CI 1.01-1.85) genetic model.
|
26112096 |
2015 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, our study provided the first evidence of association between rs895819 and PCa risk, as well as for its genetic association with the presence of distant metastases among PCa patients.
|
26112096 |
2015 |
|
Secondary Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, our study provided the first evidence of association between rs895819 and PCa risk, as well as for its genetic association with the presence of distant metastases among PCa patients.
|
26112096 |
2015 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor allele C of rs895819 was found to be associated with the increased risk of developing PCa under dominant (P=0.035; OR=1.38, 95%CI 1.02-1.86) and overdominant (P=0.04; OR=1.37, 95%CI 1.01-1.85) genetic model.
|
26112096 |
2015 |
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study provides the first evidence that the miR-27a rs895819 polymorphism is associated with a decreased risk of cervical cancer in southern Chinese women.
|
24380734 |
2014 |
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study provides the first evidence that the miR-27a rs895819 polymorphism is associated with a decreased risk of cervical cancer in southern Chinese women.
|
24380734 |
2014 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study provides the first evidence that the miR-27a rs895819 polymorphism is associated with a decreased risk of cervical cancer in southern Chinese women.
|
24380734 |
2014 |
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene.
|
25399405 |
2014 |
|
Unilateral Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further studies showed a significant association between the [G] allele of rs895819 and decreased risk of breast cancer (0.91; 95%CI, 0.85-0.98), and stratified analyses indicated a protective effect of the [G] allele in Caucasians (OR, 0.89; 95%CI, 0.82-0.98), younger breast cancer cases (OR, 0.87; 95%CI, 0.79-0.96), and in the group of unilateral breast cancer patients (OR, 0.90; 95%CI, 0.83-0.97).
|
25556434 |
2014 |
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene.
|
25399405 |
2014 |
|
Unilateral Breast Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further studies showed a significant association between the [G] allele of rs895819 and decreased risk of breast cancer (0.91; 95%CI, 0.85-0.98), and stratified analyses indicated a protective effect of the [G] allele in Caucasians (OR, 0.89; 95%CI, 0.82-0.98), younger breast cancer cases (OR, 0.87; 95%CI, 0.79-0.96), and in the group of unilateral breast cancer patients (OR, 0.90; 95%CI, 0.83-0.97).
|
25556434 |
2014 |
|
Intestinal metaplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using participants with superficial gastritis and mild chronic atrophic gastritis as the reference group, we found that rs2910164 CC carriers had a significantly increased risk of intestinal metaplasia [adjusted odds ratio (OR), 1.42; 95% confidence interval (CI), 1.03-1.97] and dysplasia (OR, 1.54; 95% CI, 1.05-2.25) compared to GG carriers, whereas no significant association was observed for rs895819.
|
23613822 |
2013 |