However, rs895819 was associated with increased risk of colorectal cancer (GG <i>vs.</i> AA: OR = 1.56, 95% CI = 1.31-1.85; GG <i>vs.</i> AA/AG: OR = 1.53, 95% CI = 1.30-1.79; G <i>vs.</i> A: OR = 1.19, 95% CI = 1.09-1.30) and lung cancer (GG <i>vs.</i> AA/AG: OR = 1.43, 95% CI = 1.00-2.04).
However, miR-196a2 rs11614913, miR-30c-1 rs928508, miR-608 rs4919510 and miR-27a rs895819 polymorphisms were not significantly associated with lung cancer risks in any models.
The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively).