|
Celiac Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
This meta-analysis provides robust estimates that IL18RAP rs917997 and CCR3 rs6441961 are potential risk factors for celiac disease in European populations.
|
26289103 |
2015 |
|
Celiac Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
Prior reports link rs917997 allele A with protection from T1D, and conversely with susceptibility to Celiac disease.
|
23891168 |
2013 |
|
Celiac Disease
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
Celiac Disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
Celiac Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
In this study, two previously indicated risk variants at the IL18RAP locus (rs13015714 and rs917997) were tested for genetic association in 1638 cases with coeliac disease and 1385 control individuals from the Finnish, Hungarian and Italian populations.
|
19103669 |
2009 |
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
BEFREE |
Joint analysis of 1851 IBD patients (1062 CD, 789 UC) and 1936 controls demonstrated strong association to the IL18RAP rs917997 SNP for both CD and UC (p(IBD) 1.9 x 10(-8); OR 1.35).
|
18439550 |
2008 |
|
Autoimmune Diseases
|
|
0.710 |
GeneticVariation
|
BEFREE |
The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.
|
23891168 |
2013 |
|
Autoimmune Diseases
|
|
0.710 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Multiple Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
Asthma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
|
21150878 |
2011 |
|
Immune System Diseases
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Lumbar disc disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a significant association among females in CT genotype of rs917997 in LDD (p = 0.041).
|
31147177 |
2019 |
|
Degeneration of lumbar intervertebral disc
|
|
0.010 |
GeneticVariation
|
BEFREE |
Hence, this study was performed to understand the role of 2 IL18RAP (rs1420106 and rs917997) polymorphisms and IL18RAP plasma levels in lumbar disc degeneration (LDD) in Indian population.
|
31147177 |
2019 |
|
Lhermitte-Duclos disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a significant association among females in CT genotype of rs917997 in LDD (p = 0.041).
|
31147177 |
2019 |
|
Gastritis, Atrophic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among 11 candidate single nucleotide polymorphisms (SNPs), subjects carrying IL-18RAP rs917997 AA genotype were associated with risk of GC [adjusted odds ratio (OR) = 1.83, 95 % confidence interval (CI) 1.14-2.92] or chronic atrophic gastritis (CAG; OR = 1.55, 95 % CI 1.07-2.24).
|
26358252 |
2016 |
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
And in another SNP rs917997, AA+AG genotype presented an increased frequency in HT subjects compared with controls (P = 0.046, OR = 1.53).
|
26566691 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among 11 candidate single nucleotide polymorphisms (SNPs), subjects carrying IL-18RAP rs917997 AA genotype were associated with risk of GC [adjusted odds ratio (OR) = 1.83, 95 % confidence interval (CI) 1.14-2.92] or chronic atrophic gastritis (CAG; OR = 1.55, 95 % CI 1.07-2.24).
|
26358252 |
2016 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among 11 candidate single nucleotide polymorphisms (SNPs), subjects carrying IL-18RAP rs917997 AA genotype were associated with risk of GC [adjusted odds ratio (OR) = 1.83, 95 % confidence interval (CI) 1.14-2.92] or chronic atrophic gastritis (CAG; OR = 1.55, 95 % CI 1.07-2.24).
|
26358252 |
2016 |
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the haplotype GAGCCCG from ST2-IL18R1-IL18RAP gene cluster (rs6543116, rs1041973, rs1035130, rs3732127, rs1035127, rs2293225, rs917997) was associated with increased susceptibility to GD with an OR of 2.03 (P = 0.022, 95% CI = 1.07-3.86).
|
26566691 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Taken together, these data suggest that the disease-associated rs917997 allele G permits hyperresponsiveness to IL-18, providing a novel target for therapeutic intervention in T1D.
|
23891168 |
2013 |
|
Esophageal Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC genotype at IL-18RAP locus rs917997 was associated with a protective effect against esophageal disease (P = 6 × 10(-4), odds ratio (OR) = 0.59, and 95% confidence interval (CI) 0.43-0.80 for BE; and P = 2 × 10(-6), OR = 0.46, and 95% CI 0.34-0.64 for EAC).
|
22664470 |
2012 |
|
Familial multiple trichoepitheliomata
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data show a strong association of the IL-18RAP SNP rs917997 locus with BE and EAC and suggestive association of the Barrett's population with the IL-18-607 C/A promoter polymorphism.
|
22664470 |
2012 |
|
Barrett Esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data show a strong association of the IL-18RAP SNP rs917997 locus with BE and EAC and suggestive association of the Barrett's population with the IL-18-607 C/A promoter polymorphism.
|
22664470 |
2012 |