rs9271366, None

N. diseases: 9
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Immunoglobulin A measurement
CUI: C0202083
Disease: Immunoglobulin A measurement
0.700 GeneticVariation GWASDB Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. 20694011 2010
Protein measurement
CUI: C0202202
Disease: Protein measurement
0.700 GeneticVariation GWASCAT Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. 20694011 2010
Rheumatoid Arthritis
CUI: C0003873
Disease: Rheumatoid Arthritis
0.700 GeneticVariation GWASDB REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. 19503088 2009
Leprosy
CUI: C0023343
Disease: Leprosy
0.700 GeneticVariation GWASDB Genomewide association study of leprosy. 20018961 2009
Rheumatoid Arthritis
CUI: C0003873
Disease: Rheumatoid Arthritis
0.700 GeneticVariation GWASDB TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. 17804836 2007
Inflammatory Bowel Diseases
CUI: C0021390
Disease: Inflammatory Bowel Diseases
0.710 GeneticVariation BEFREE The strongest associations were observed between ulcerative colitis and HLA rs9271366 (P = 7.5 × 10(-6)), Crohn's disease and 5p13.1 rs4286721 (P = 3.5 × 10(-6)), and IBD and KAT2A rs730086 (P = 2.3 × 10(-6)). 26278503 2015
Inflammatory Bowel Diseases
CUI: C0021390
Disease: Inflammatory Bowel Diseases
0.710 GeneticVariation GWASDB HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. 21699788 2011
Inflammatory Bowel Diseases
CUI: C0021390
Disease: Inflammatory Bowel Diseases
0.710 GeneticVariation GWASDB HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. 21699788 2011
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.800 GeneticVariation GWASDB Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. 20598377 2010
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.800 GeneticVariation GWASCAT Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. 20598377 2010
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.800 GeneticVariation GWASDB Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. 19525955 2009
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.800 GeneticVariation GWASCAT Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. 19525955 2009
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.810 GeneticVariation GWASCAT Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. 23511034 2013
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.810 GeneticVariation GWASDB Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. 23511034 2013
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.810 GeneticVariation GWASCAT The comparative GWAS and the replication study identified significant associations in the major histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 × 10⁻⁷⁰; odds ratio [OR] = 4.44). 21699788 2011
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.810 GeneticVariation BEFREE The comparative GWAS and the replication study identified significant associations in the major histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 × 10⁻⁷⁰; odds ratio [OR] = 4.44). 21699788 2011
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.820 GeneticVariation BEFREE The strongest associations were observed between ulcerative colitis and HLA rs9271366 (P = 7.5 × 10(-6)), Crohn's disease and 5p13.1 rs4286721 (P = 3.5 × 10(-6)), and IBD and KAT2A rs730086 (P = 2.3 × 10(-6)). 26278503 2015
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.820 GeneticVariation GWASDB Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. 23850713 2014
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.820 GeneticVariation GWASCAT Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. 23850713 2014
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.820 GeneticVariation GWASDB A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. 23266558 2013
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.820 GeneticVariation BEFREE The comparative GWAS and the replication study identified significant associations in the major histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 × 10⁻⁷⁰; odds ratio [OR] = 4.44). 21699788 2011
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.820 GeneticVariation GWASCAT The comparative GWAS and the replication study identified significant associations in the major histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 × 10⁻⁷⁰; odds ratio [OR] = 4.44). 21699788 2011
Lupus Erythematosus, Systemic
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
0.840 GeneticVariation BEFREE In this cohort, SNP rs9271366 (tag SNP for HLA-DRB1*15:01) confers the highest risk for SLE among the 13 MHC gene alleles that display association with SLE (p = 8.748E-10; OR = 3.5). 31032751 2019
Lupus Erythematosus, Systemic
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
0.840 GeneticVariation BEFREE The IRF5-TNPO3 region showed the strongest association and largest OR for SLE (rs10488631: genomic control-adjusted P [Pgcadj ] = 2.61 × 10(-29), OR 2.12 [95% CI 1.88-2.39]), followed by HLA class II on the DQA2-DQB1 loci (rs9275572: Pgcadj  = 1.11 × 10(-16), OR 1.62 [95% CI 1.46-1.80] and rs9271366: Pgcadj  = 6.46 × 10(-12), OR 2.06 [95% CI 1.71-2.50]). 26606652 2016
Lupus Erythematosus, Systemic
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
0.840 GeneticVariation GWASDB Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013