rs9282858, SRD5A2

N. diseases: 16
Disease: Benign Prostatic Hyperplasia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Benign Prostatic Hyperplasia
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
0.060 GeneticVariation BEFREE <b>Results:</b><i>SRD5A2</i> rs9282858 (A49T) polymorphism showed a significant correlation with increased B</span>PH susceptibility under allele T vs.allele A genetic model (OR = 2.51, 95% CI = 1.29-4.88) in total analysis, and stratification analysis by ethnicity also revealed a similar association in Caucasian group under the same contrast. 28955247 2017
Benign Prostatic Hyperplasia
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
0.060 GeneticVariation BEFREE We found statistically significant relationship between the SRD5A2 gene Ala49Thr (OR=2.3; CI 95%, 1.04-5.1; p=0.01<0.05) , but not the other polymorphisms, and B</span>PH. 21627373 2011
Benign Prostatic Hyperplasia
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
0.060 GeneticVariation BEFREE Prostate cancer and BPH were not associated with the alanine-49 to threonine single nucleotide polymorphism and the (TA)n repeat. 16018939 2005
Benign Prostatic Hyperplasia
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
0.060 GeneticVariation BEFREE The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n=89), benign prostate hyperplasia (n=45) and healthy military conscripts (n=223). 16039774 2005
Benign Prostatic Hyperplasia
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
0.060 GeneticVariation BEFREE The A49T and TA repeat polymorphisms were not associated with BPH. 15389785 2005
Benign Prostatic Hyperplasia
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
0.060 GeneticVariation BEFREE The enzyme is a target in pharmacological treatment of benign prostatic hyperplasia using specific inhibitors such as finasteride.Makridakis et al. have characterized the V89L and A49T polymorphisms in recombinant expression systems. 12042668 2002