Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Differentiated Thyroid Gland Carcinoma
0.070 GeneticVariation BEFREE This meta-analysis revealed that common variations of FOXE1 (rs965513, rs944289 and rs1867277) were risk factors associated with increased DTC susceptibility. 29788924 2018
Differentiated Thyroid Gland Carcinoma
0.070 GeneticVariation BEFREE Five germline genetic variants (rs116909374, rs965513, rs944289, rs966423, and rs2439302) have been associated in genome-wide association studies (GWAS) with increased risk of differentiated thyroid cancer (DTC), but their role in mortality of patients has not been established. 26490305 2016
Differentiated Thyroid Gland Carcinoma
0.070 GeneticVariation BEFREE Among Europeans, we found that the two SNPs previously reported at 9q22 were not independently associated to DTC and that rs965513 was the predominant signal; at 14q13, we showed that the haplotype rs944289[C]-rs116909374[C]-rs999460[T] was significantly associated with DTC risk and that the association with rs116909374 differed by smoking status (p-interaction = 0.03). 26991144 2016
Differentiated Thyroid Gland Carcinoma
0.070 GeneticVariation BEFREE Furthermore, DTC risk was positively associated with the number of copies in the minor allele (A) of rs965513 among people who consumed less iodine than the median. 27610545 2016
Differentiated Thyroid Gland Carcinoma
0.070 GeneticVariation BEFREE For the GWAS SNP rs965513 near FOXE1, an association was found between genotypes G/A and A/A, and risk of DTC. 25849217 2015
Differentiated Thyroid Gland Carcinoma
0.070 GeneticVariation BEFREE Significant association with DTC risk was found for rs944289 near NKX2-1 (OR per A allele = 1.6, 95% CI: 1.2-2.1), and three polymorphisms near or within FOXE1, namely rs965513 (OR per A allele = 1.7, 95% CI: 1.2-2.3), rs1867277 in the promoter region of the gene (OR per A allele = 1.5, 95% CI: 1.1-1.9) and the poly-alanine tract expansion polymorphism rs71369530 (OR per Long Allele = 1.8, 95% CI: 1.3-2.5), only the 2 latter remaining significant when correcting for multiple tests. 25879635 2015
Differentiated Thyroid Gland Carcinoma
0.070 GeneticVariation BEFREE Our results confirm that the FOXE1 rs965513 SNP confers an increased risk for DTC in the German population, particularly allele "A" and the genotypes "AA" and "AG" for PTC. 24325646 2014