|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
The A allele of rs965513 polymorphism was shown to be highly associated with risk of thyr</span>oid cancer, with odds ratios of 1.58 (95% CI 1.32-1.90) in all populations, 1.65 (95% CI 1.31-2.07)) in Caucasian populations and 1.49 in Asian populations.
|
27191655 |
2016 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations.
|
25855579 |
2015 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
These results explain the mechanism by which the risk allele of rs965513 predisposes to thyroid cancer.
|
25918370 |
2015 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
For rs965513, individuals carrying the risk A allele, compared to individuals with the G allele, had 31 % higher risk of thyroid cancer (A vs. G: OR 1.31, 95 % CI 1.17-1.46).
|
26206751 |
2015 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Genome-wide association study on differentiated thyroid cancer.
|
23894154 |
2013 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASDB |
Genome-wide association study on differentiated thyroid cancer.
|
23894154 |
2013 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
Five single nucleotide polymorphisms (SNPs) were previously reported to be associated with thyroid cancer in European populations in two genome-wide association studies (GWAS): rs965513 (9q22.33), rs944289 (14q13.3), rs116909374 (14q13.3), rs966423 (2q35) and rs2439302 (8p12).
|
23847140 |
2013 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
The four validated TC SNPs accounted for a relatively large proportion (∼11%) of the sibling relative risk of TC, principally owing to the large effect size of rs965513 (OR 1.74).
|
22282540 |
2012 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
Of those, rs965513 has previously been shown to associate with thyroid cancer.
|
22267200 |
2012 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASDB |
Of those, rs965513 has previously been shown to associate with thyroid cancer.
|
22267200 |
2012 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASDB |
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
|
20350937 |
2010 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASCAT |
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
|
20350937 |
2010 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
|
19198613 |
2009 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASDB |
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
|
19198613 |
2009 |
|
Hypothyroidism
|
|
0.700 |
GeneticVariation
|
GWASDB |
Novel associations for hypothyroidism include known autoimmune risk loci.
|
22493691 |
2012 |
|
Polysomnography
|
|
0.700 |
GeneticVariation
|
GWASDB |
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
23251661 |
2012 |
|
Hypothyroidism
|
|
0.700 |
GeneticVariation
|
GWASDB |
Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies.
|
21981779 |
2011 |
|
Nasopharyngeal carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The functional variants rs965513 and rs1867277 independently contribute to genetic predisposition to PTC, while a contributing role of the FOXE1 poly-Ala polymorphism could not be confirmed.
|
27824288 |
2017 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were significant associations of all SNPs with PTC (rs965513 odds ratio [OR] = 1.72, p = 8 × 10-7; rs1867277 OR = 1.59, p = 1 × 10-6; rs1443434 OR = 1.53, p = 1 × 10-5; rs944289 OR = 1.52, p = 4 × 10-5).
|
28660995 |
2017 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We propose that the interaction between the lncRNA, its binding protein MYH9, and the coding gene FOXE1 underlies the predisposition to PTC triggered by rs965513.
|
28049826 |
2017 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the association between rs965513 and PTC in different ethnicities and countries, we conducted a meta-analysis using relatively large-scale samples from 23 studies (N = 163,136; 20,736 cases and 142,400 controls) by searching the PubMed and Google Scholar databases.
|
27191655 |
2016 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped rs965513 from PTC patients and measured gene expression levels by real-time RT-PCR in unaffected thyroid tissue and matched tumor.
|
25303483 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four GWAS-identified SNPs of papillary thyroid cancer (PTC), rs965513, rs944289, rs966423 and rs2439302, were genotyped in a case-control study of 838 patients with PTC and 501 patients with benign thyroid tumor (BTT) from the Chinese Han population.
|
25746573 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC</span>) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood.
|
25918370 |
2015 |