Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the FTO rs9939609 SNP was associated with an increased risk for MetS in this multi-ethnic sample, confirming that the association extends to non-Caucasian population samples.
|
18339204 |
2008 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004).
|
18853134 |
2008 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS.
|
21749608 |
2011 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10(-5)) and rs1421085 (P=7.4 × 10(-5)). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome.
|
21796137 |
2011 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
This association remains after excluding rs9939609, a SNP that was frequently reported to have strong association with obesity and MetS.
|
22189543 |
2012 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, FTO rs9939609 was associated with obesity measures, especially in those with the MetS, which was further exacerbated by high dietary SFA intake at baseline and 7.5 y later.
|
22457394 |
2012 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggested that FTO rs9939609</span> polymorphism was significantly associated with the increased risk of MetS in European and Asian populations.
|
22311015 |
2012 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs9939609 polymorphism was not associated with MetS, elevated waist circumference or BMI, or diabetic complications.
|
21741858 |
2012 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Only three of the 16 polymorphisms studied showed significant association with MS; rs9939609 of the FTO gene confers risk for MS (odds ratio [OR]: 1.73, 95% CI: 1.07-2.78, p = 0.026), while rs1137101 of the LEPR gene (OR: 0.47, 95% CI: 0.28-0.80, p = 0.005) and rs1801133 of the MTHFR gene (OR: 0.59, 95% CI: 0.35-0.99, p = 0.049) are protective against MS.
|
24624915 |
2014 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Fat Mass and Obesity-Associated Protein (FTO) gene rs9939609 single nucleotide polymorphism (SNP) has been associated with obesity, metabolic syndrome, insulin resistance (IR), and type 2 diabetes mellitus in the general population.
|
25367448 |
2014 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, the FTO rs9939609 genotype accounted for 21.3% of the MetS phenotype together with total cholesterol, BMR and age.
|
24675148 |
2014 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The FTO gene polymorphism (rs9939609) was found to be associated with increased insulin resistance, insulin and triglyceride levels in obese females with TT variant and without metabolic syndrome.
|
23490278 |
2014 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype distribution of the variant rs9939609 was different between MetS and controls (P = 0.017).
|
26741700 |
2016 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The FTO rs9939609 polymorphism was associated with anthropometric parameters and metabolic syndrome in the younger age group (25-44 years) and in individuals having low level of physical activity.
|
27003669 |
2016 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA was extracted from the whole blood of 192 natural postmenopausal women (40 to 65 years) screened for the METS and tested for three gene SNPs related to obesity: the fat mass obesity (FTO: rs9939609) and the methylenetetrahydrofolate reductase (MTHFR: C677T and A1298C).
|
26902996 |
2016 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study shows for first time that FTO gene rs9939609 is genetic risk factor for metabolic syndrome in Egyptian population which may help in understanding the biology of this complex syndrome and highlighted that this association may be through HDL-C component.
|
28915859 |
2017 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
BACKGROUND The distribution of fat mass and obesity-associated gene (FTO) genes rs9939609 and rs1421085 in obese and normal ethnic Mongolians was analyzed to investigate the association of FTO gene polymorphisms with obesity and metabolic syndrome in ethnic Mongolians.
|
30442880 |
2018 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that ALE supplementation may improve serum triglyceride level in A allele genotype of FTO-rs9939609 polymorphism in women with MetS.
|
29193419 |
2018 |