rs9939609, FTO

N. diseases: 98
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE FTO rs9939609 was associated with risk of obesity in additive model (p=0.031), recessive (p=0.033) and with altered WC in all models. 30713021 2020
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE FTO rs9939609 had an obvious and independent effect on obesity-related indices in early adolescents. 31402168 2020
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity. 29334686 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE Findings of the present study highlight the association between FTO rs9939609 and obesity or body fat indices in girls but not in boys. 31444941 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients. 31836807 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE Of interest, a markedly lower frequency of the FTO rs9939609 obesity risk A-allele was found in BED patients (0.290) in relation to the control group (0.402). 30677719 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The FTO rs9939609 polymorphism and obesity risk in teens: Evidence-based meta-analysis. 30104138 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE Psoriatic patients, carriers of risk allele of <i>FTO</i> gene rs9939609, have an increased risk for more severe psoriasis and obesity and may develop obesity-induced insulin resistance. 30733965 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The rs9939609 affected the response to dietary intervention in obese women: A allele carriers reduced 2.7 cm less of abdominal circumference (AC) than homozygous TT (p = 0.04), while no effect was observed in response to physical exercise in overweight and obese children and adolescents. 29238857 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE DNA samples were genotyped for the rs9939609 polymorphism in the obesity-linked gene <i>FTO</i>. 30759834 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE These findings suggest that Indonesian adults with AT/AA genotypes of the FTO rs9939609 have higher obesity risks and preferences for high dietary fat intake than those with TT genotype. 30896430 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been associated with obesity, and studies have also shown that environmental/lifestyle interaction such as dietary intake might mediate this effect. 31635368 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is associated with higher acyl-ghrelin (AG) concentrations, higher energy intake, and obesity, although exercise may mitigate rs9939609 A-allele-linked obesity risk. 31504106 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity. 30896429 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The fat mass and obesity-related (FTO) single-nucleotide polymorphism (SNP) rs9939609 is a major SNP associated with obesity and has been used as an instrumental variable for obesity in a Mendelian randomization (MR) approach. 31401654 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The aim of this study is to investigate whether the genetic risk score (GRS) based on previously associated obesity polymorphisms (SNP) rs9939609 (fat mass and obesity-associated (FTO)), rs6548238 (transmembrane protein 18 (TMEM18)) and rs16835198 (fibronectin type III domain containing 5 (FNDC5)) could serve as a predictor for anthropometric characteristics in a sample of Brazilian children and adolescents. 30311592 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE FTO SNPs rs1421085 and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys. 30537186 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE We investigated a </span>possible association of ADIPOQ rs2241766 G>T, FTO rs9939609</span> A>T and ACE rs4340288 DIP variants among obese and non-obese Turkish Cypriot origin. 30416093 2019
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The FTO polymorphisms were associated with a significantly increased risk for obesity and in BMI-stratified cohort, rs9939609 (T/A: odds ratio [OR] = 1.73, p = 0.007) and rs1421085 (T/C: OR = 1.56, p = 0.03) showed even stronger association. 29466028 2018
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE We observed an association between the common FTO rs9939609 polymorphism and increased BMI (overweight/obesity) in Kuwaiti adults, which is consistent with previous research in other populations. 29402776 2018
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE MAF of G2548A was 42.8% in obese and 30.1% in controls (<i>P</i>=5.7 × 10<sup>-5</sup>), it showed association with weight, body mass index (BMI), waist circumference (WC), high density lipoprotein cholesterol (HDL-c) and leptin, Gln223Arg had MAF 32% in obese and 18.7% in controls (<i>P</i>=5.4 × 10<sup>-6</sup>), it showed association with fasting plasma glucose (FPG) and all lipid traits, Ala54Thr had MAF 42.4% in obese and 33.1% (<i>P</i>=0.002), it showed association with none of the tested parameters. rs9939609 MAF was 26.6%, and showed association with none of the tested parameters. rs1802295 (<i>P</i>=0.002); rs7178572 (<i>P</i>=0.007); rs2028299 (<i>P</i>=0.04); rs4812829 (<i>P</i>=0.02) showed significant while rs3923113 and rs16861329 did not show a significant association (<i>P</i>=0.20 and <i>P</i>=0.3, respectively) with obesity. 29752338 2018
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE To examine the associations of two obesity-associated genes, FTO (rs9939609) and GNB3 (rs5443) single nucleotide polymorphisms (SNPs), with early pregnancy body mass index, gestational weight gain, and postpartum weight retention. 29469022 2018
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE We performed a cross-sectional study in a sample that was enriched for obesity and included 20 higher-risk participants with the AA (risk) genotype at the rs9939609 locus of FTO and 94 lower-risk participants with either the AT or TT genotype. 29529147 2018
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE To the best of the author's knowledge this is the first study, associating FTO rs9939609</span> gene polymorphism and obesity in the North-eastern Indian tribal populations with East-Asian ancestry. 29317321 2018
Obesity
CUI: C0028754
Disease: Obesity
0.800 GeneticVariation BEFREE The risk of obesity in Mongolian individuals carrying rs</span>9939609 AT genotype was 1.312 times higher and the risk in those carrying AA genotype was 1.896 times higher than in individuals with TT genotype. 30442880 2018